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Well-Demarcated Nasopharyngeal Mass in an Adolescent Male

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
1 Credit CME

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Article Information

Corresponding Author: Ju Wan Kang, MD, PhD, Department of Otorhinolaryngology, Gangnam Severance Hospital Yonsei University College of Medicine, 2111, Eonju-ro, Gangnam-gu, Seoul 06237, Republic of Korea (juwankangmd@gmail.com).

Published Online: June 24, 2021. doi:10.1001/jamaoto.2021.1235

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

Additional Information: The institutional review board of Jeju National University Hospital approved this study.

References
1.
Gaba  AR , Stein  RS , Sweet  DL , Variakojis  D .  Multicentric giant lymph node hyperplasia.   Am J Clin Pathol. 1978;69(1):86-90. doi:10.1093/ajcp/69.1.86PubMedGoogle ScholarCrossref
2.
Wang  W , Medeiros  LJ .  Castleman disease.   Surg Pathol Clin. 2019;12(3):849-863. doi:10.1016/j.path.2019.03.003PubMedGoogle ScholarCrossref
3.
Herrada  J , Cabanillas  F , Rice  L , Manning  J , Pugh  W .  The clinical behavior of localized and multicentric Castleman disease.   Ann Intern Med. 1998;128(8):657-662. doi:10.7326/0003-4819-128-8-199804150-00010PubMedGoogle ScholarCrossref
4.
McDonnell  O , Morris  M , Khaleel  Z .  Isolated nasopharyngeal Castleman disease: an uncommon diagnosis in an unusual location.   Case Rep Radiol. 2014;2014:475690. doi:10.1155/2014/475690PubMedGoogle Scholar
5.
Soumerai  JD , Sohani  AR , Abramson  JS .  Diagnosis and management of Castleman disease.   Cancer Control. 2014;21(4):266-278. doi:10.1177/107327481402100403PubMedGoogle ScholarCrossref
6.
Wenig  BM , Heffner  DK .  Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases.   Ann Otol Rhinol Laryngol. 1995;104(8):639-645. doi:10.1177/000348949510400809PubMedGoogle ScholarCrossref
7.
Chronowski  GM , Ha  CS , Wilder  RB , Cabanillas  F , Manning  J , Cox  JD .  Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy.   Cancer. 2001;92(3):670-676. doi:10.1002/1097-0142(20010801)92:3<670::AID-CNCR1369>3.0.CO;2-QPubMedGoogle ScholarCrossref
8.
Larroche  C , Cacoub  P , Soulier  J ,  et al.  Castleman’s disease and lymphoma: report of eight cases in HIV-negative patients and literature review.   Am J Hematol. 2002;69(2):119-126. doi:10.1002/ajh.10022PubMedGoogle ScholarCrossref
9.
Chan  AC , Chan  KW , Chan  JK , Au  WY , Ho  WK , Ng  WM .  Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies.   Histopathology. 2001;38(6):510-518. doi:10.1046/j.1365-2559.2001.01134.xPubMedGoogle ScholarCrossref
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