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Approximately 2% of all full-term neonates are evaluated for fever in the first months of life, and there exists significant ongoing variation in their care.1 Although most febrile neonates and infants 90 days or younger (hereafter referred to as young infants) have self-limited viral illnesses, the prevalence of life-threatening serious bacterial infections (SBIs) has remained approximately 10% for more than 30 years.1 On March 11, 2020, the COVID-19 pandemic was declared, and since that time, studies worldwide have reported a 30% to 89% reduction in the number of children brought to emergency care2,3 as well as fewer circulating respiratory viruses owing to widespread COVID-19 public health mitigation strategies.4,5 To our knowledge, the epidemiologic characteristics of SBIs among febrile young infants during the COVID-19 pandemic has not previously been assessed. We sought to assess the prevalence of SBIs among febrile young infants evaluated in the emergency department (ED) for fever during the COVID-19 pandemic.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: May 6, 2021.
Published: July 13, 2021. doi:10.1001/jamanetworkopen.2021.16919
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Burstein B et al. JAMA Network Open.
Corresponding Author: Brett Burstein, MD, CM, PhD, MPH, Montreal Children’s Hospital, Division of Pediatric Emergency Medicine, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4C 3J1, Canada (email@example.com).
Author Contributions: Dr Burstein and Ms Yannopoulos had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Burstein.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Burstein.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Burstein.
Administrative, technical, or material support: Anderson, Yannopoulos.
Conflict of Interest Disclosures: None reported.
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