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Incidence of Axillary Adenopathy in Breast Imaging After COVID-19 Vaccination

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Vaccine-induced adenopathy after COVID-19 vaccination in breast imaging has received significant media attention, with evolving literary correspondence on management. Patients’ self-report of axillary swelling following COVID-19 vaccination was reported as high as 16%.1 The National Comprehensive Cancer Network and Society of Breast Imaging recommended to consider scheduling screening breast imaging 4 to 6 weeks after the second COVID-19 vaccination dose when possible.2 However, the actual incidence, timing, and characteristics of mammographic axillary adenopathy following COVID-19 vaccination remain uncertain.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: May 25, 2021.

Published Online: July 22, 2021. doi:10.1001/jamaoncol.2021.3127

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Robinson KA et al. JAMA Oncology.

Corresponding Author: Saranya Chumsri, MD, Division of Hematology and Medical Oncology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224 (chumsri.saranya@mayo.edu).

Author Contributions: Dr Chumsri had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Robinson, Maimone, Advani, Chumsri.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Robinson, Maimone, Advani, Chumsri.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Maimone, Li, Advani, Chumsri.

Obtained funding: Chumsri.

Administrative, technical, or material support: Chumsri.

Supervision: Maimone, Chumsri.

Conflict of Interest Disclosures: Dr Advani reported grants from Genentech during the conduct of the study. Dr Chumsri reported grants from Pfizer during the conduct of the study; grants from Merck & Co, the Department of Defense, and the Breast Cancer Research Foundaiton; and personal fees from Novartis, Immunomedics, Puma Biotechnology, BioTheranostics, AstraZeneca, Eisai, Athenex, and Daiichi Sankyo outside the submitted work. No other disclosures were reported.

Funding/Support: Research reported in this publication was supported by Mayo Clinic.

Role of the Funder/Sponsor: The Mayo Clinic had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
US Centers for Disease Control. Local reactions, systemic reactions, adverse events, and serious adverse events: Moderna COVID-19 Vaccine. Accessed June 15, 2021. https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/reactogenicity.html
2.
National Comprehensive Cancer Network. Recommendations of the NCCN COVID-19 Vaccination Advisory Committee. Accessed June 15, 2021. https://www.nccn.org/docs/default-source/covid-19/2021_covid-19_vaccination_guidance_v3-0.pdf?
3.
Lehman  CD , Lamb  LR , D’Alessandro  HA .  Mitigating the impact of coronavirus disease (COVID-19) vaccinations on patients undergoing breast imaging examinations: a pragmatic approach.   AJR Am J Roentgenol. Published online February 22, 2021. doi:10.2214/AJR.21.25688PubMedGoogle Scholar
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