Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples | Geriatrics | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Vaccination with 2 doses of the BNT162b2 vaccine (Pfizer-BioNTech) reportedly provides 95% protection from COVID-19.1 However, patient age is known to contribute to the risk of COVID-19 incidence and severity.2 We examined the relationship between age and neutralizing antibody titers against the early SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant of concern after 2 doses of the BNT162b2 vaccine.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Article Information

Corresponding Author: Fikadu G. Tafesse, PhD, Department of Molecular Microbiology & Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 (tafesse@ohsu.edu).

Accepted for Publication: June 29, 2021.

Published Online: July 21, 2021. doi:10.1001/jama.2021.11656

Author Contributions: Dr Tafesse had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Mr Bates and Mr Leier contributed equally to this work.

Concept and design: Bates, Leier, Lyski, Curlin, Messer, Tafesse.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Bates, Leier.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Bates, Messer.

Obtained funding: Curlin, Messer, Tafesse.

Administrative, technical, or material support: Bates, Lyski, Goodman, Curlin, Tafesse.

Supervision: Curlin, Messer, Tafesse.

Conflict of Interest Disclosures: Dr Curlin reported receiving grants from the M.J. Murdock Charitable Trust and the Oregon Health & Science University Foundation for unrestricted COVID-19 research during the conduct of the study. Dr Tafesse reported receiving grants from Oregon Health & Science University Biomedical Innovation Program during the conduct of the study. No other disclosures were reported.

Funding/Support: This study was funded in part by an unrestricted grant from the M.J. Murdock Charitable Trust, by National Institutes of Health training grant T32AI747225 on Interactions at the Microbe-Host Interface, Oregon Health & Science University Innovative IDEA grant 1018784, and National Institutes of Health grant R01AI145835.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: We acknowledge the efforts of the Oregon Health & Science University COVID-19 serology research team for their assistance with sample acquisition, data collection, and statistical analysis, including Christopher Malibiran, BS; Cynthia Martinez, BS; David Xthona Lee, BA; Devin Schoen, BS; Felicity Coulter, MS; Haley Miller, BS; Hiro Ross, BS; Joseph Easly, BS; Kristin Bialobok, MSN; Laura Craft, BS; Madison Egan, BS-RD; Madison Wahl, BA; Marcus Curlin; Mari Tasche, BS; Matthew Strnad, BS; Maya Herzig, BS; Olivia Glatt, BA; Peter Sullivan, BA; Rick Mathews, BE; Sara McCrimmon, MPH; Sarah Siegel, PhD; Taylor Anderson, MD; Teresa Xu, BA; and Zhengchun Lu, MBBS-PhD. We also thank Savannah McBride, BA (Department of Molecular Microbiology & Immunology, Oregon Health & Science University), for technical help and Endale Tafesse, PhD (Department of Plant Sciences, University of Saskatchewan), for advice on data analysis. None of these individuals were compensated for their contributions. We are deeply grateful for the Oregon Health & Science University faculty, staff, and patients who contributed to this study.

References
1.
Polack  FP , Thomas  SJ , Kitchin  N ,  et al; C4591001 Clinical Trial Group.  Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine.   N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577PubMedGoogle ScholarCrossref
2.
Kontopantelis  E , Mamas  MA , Deanfield  J , Asaria  M , Doran  T .  Excess mortality in England and Wales during the first wave of the COVID-19 pandemic.   J Epidemiol Community Health. 2021;75(3):213-223. doi:10.1136/jech-2020-214764PubMedGoogle Scholar
3.
Haas  EJ , Angulo  FJ , McLaughlin  JM ,  et al.  Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data.   Lancet. 2021;397(10287):1819-1829. doi:10.1016/S0140-6736(21)00947-8PubMedGoogle ScholarCrossref
4.
Baden  LR , El Sahly  HM , Essink  B ,  et al; COVE Study Group.  Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine.   N Engl J Med. 2021;384(5):403-416 doi:10.1056/NEJMoa2035389PubMedGoogle ScholarCrossref
5.
Khoury  DS , Cromer  D , Reynaldi  A ,  et al.  Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.   Nat Med. Published online May 17, 2021. doi:10.1038/s41591-021-01377-8PubMedGoogle Scholar
6.
 COVID-19 vaccine breakthrough infections reported to CDC—United States, January 1-April 30, 2021.   MMWR Morb Mortal Wkly Rep. 2021;70(21);792–793. doi:10.15585/mmwr.mm7021e3PubMedGoogle ScholarCrossref
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close