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Infectious Diseases

Self-reported Memory Problems 8 Months After COVID-19 Infection

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To identify the key insights or developments described in this article

1 Credit CME

JAMA Network Open

Published Online: July 29, 2021

Research Letter

Article Information and Disclosures

Arne Søraas, PhD¹;

Ragnhild Bø, PhD²;

Karl Trygve Kalleberg, PhD³;

Nathalie C. Støer, PhD⁴;

Merete Ellingjord-Dale, PhD¹;

Nils Inge Landrø, PhD⁵

Author Affiliations

¹Department of Microbiology, Oslo University Hospital, Oslo, Norway
²Department of Psychology, University of Oslo, Oslo, Norway
³Age Labs AS, Oslo, Norway
⁴Cancer Registry of Norway, Oslo, Norway
⁵Department of Psychology, University of Oslo, Oslo, Norway

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COVID-19 is an airway disease that also affects the nervous system.¹ Therefore, neurological and neurocognitive symptoms may be a part of the postacute sequelae of SARS-CoV-2 infection (PASC) syndrome. PASC may be found to affect a high proportion of people who had mild cases of COVID-19, and there is an urgent need for a detailed description of PASC in nonhospitalized patients.²^,3 This cohort study examines self-reported memory problems 8 months after COVID-19 infection.

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Article Information

Accepted for Publication: May 21, 2021.

Published: July 29, 2021. doi:10.1001/jamanetworkopen.2021.18717

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Søraas A et al. JAMA Network Open.

Corresponding Author: Arne Søraas, PhD, Department of Microbiology, Oslo University Hospital, Pb 4950, 0424 Oslo, Norway (arvsoe@ous-hf.no).

Author Contributions: Dr Søraas had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Søraas, Bø, Kalleberg.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Søraas, Kalleberg.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Søraas, Støer.

Administrative, technical, or material support: Søraas, Kalleberg.

Supervision: Søraas, Ellingjord-Dale.

Conflict of Interest Disclosures: Dr Søraas reported being an employee and shareholder at Age Labs outside of the submitted work. Dr Kalleberg reported receiving grants from the Norwegian Research Council during the conduct of the study and being a shareholder at Age Labs outside of the submitted work. No other disclosures were reported.

Additional Contributions: We thank Eyvind Axelsen, PhD; Andreas Lind, MD, PhD; Roar Bævre-Jensen, MD; and Silje Bakken Jørgensen, MD, PhD for contributing to the participant recruitment in this study. We also thank Mette Istre, MSc, for her contribution to establishing the cohort. Written permissions to include these nonauthors have been obtained and no one was compensated for their work.

Additional Information: The manuscript has been published on a preprint server.

References

Kandemirli SG , Dogan L , Sarikaya ZT , et al. Brain MRI findings in patients in the intensive care unit with COVID-19 infection. Radiology. 2020;297(1):E232-E235. doi:10.1148/radiol.2020201697 PubMed Google Scholar Crossref

Norton A , Olliaro P , Sigfrid L , et al; ISARIC and GloPID-R Long COVID Forum Working Group. Long COVID: tackling a multifaceted condition requires a multidisciplinary approach. Lancet Infect Dis. 2021;21(5):601-602. doi:10.1016/S1473-3099(21)00043-8 PubMed Google Scholar Crossref

Munblit D , Bobkova P , Spiridonova E , et al. Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study. medRxiv. 2021:2021.2002.2017.21251895. doi:10.1101/2021.02.17.21251895 Google Scholar

Kjetland EF , Kalleberg KT , Søraas CL , et al. Risk factors for community transmission of SARS-CoV-2: a cross-sectional study in 116,678 people. medRxiv. 2020:2020.2012.2023.20248514. doi:10.1101/2020.12.23.20248514 Google Scholar

Landrø NI , Fors EA , Våpenstad LL , Holthe Ø , Stiles TC , Borchgrevink PC . The extent of neurocognitive dysfunction in a multidisciplinary pain centre population: is there a relation between reported and tested neuropsychological functioning? Pain. 2013;154(7):972-977. doi:10.1016/j.pain.2013.01.013 PubMed Google Scholar Crossref

Reisberg B , Shulman MB , Torossian C , Leng L , Zhu W . Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimers Dement. 2010;6(1):11-24. doi:10.1016/j.jalz.2009.10.002 PubMed Google Scholar Crossref

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