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Gastroenterology and Hepatology

Trends in Liver Transplantation for Acute Alcohol-Associated Hepatitis During the COVID-19 Pandemic in the US

Educational Objective
To identify the key insights or developments described in this article

1 Credit CME

JAMA Network Open

Published Online: July 29, 2021

Research Letter

Article Information and Disclosures

Therese Bittermann, MD¹;

Nadim Mahmud, MD¹;

Peter Abt, MD¹

Author Affiliations

¹Perelman School of Medicine, University of Pennsylvania, Philadelphia

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Alcohol consumption and alcohol-related hospitalizations in the US have increased since the start of the COVID-19 pandemic.¹^,2 The broader public health consequences associated with these trends are incompletely characterized. Liver transplantation has become an accepted treatment for severe, acute alcohol-associated hepatitis.³ We describe trends in liver transplantation for acute alcohol-associated hepatitis before and during the COVID-19 pandemic.

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Article Information

Accepted for Publication: May 21, 2021.

Published: July 29, 2021. doi:10.1001/jamanetworkopen.2021.18713

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Bittermann T et al. JAMA Network Open.

Corresponding Author: Therese Bittermann, MD, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (therese.bittermann@pennmedicine.upenn.edu).

Author Contributions: Dr Bittermann had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: All authors.

Critical revision of the manuscript for important intellectual content: Mahmud, Abt.

Statistical analysis: Bittermann, Mahmud.

Administrative, technical, or material support: Abt.

Supervision: Abt.

Conflict of Interest Disclosures: None reported.

References

Barbosa C , Cowell AJ , Dowd WN . Alcohol consumption in response to the COVID-19 pandemic in the United States. J Addict Med. 2020. doi:10.1097/ADM.0000000000000767 PubMed Google Scholar

Sharma RA , Subedi K , Gbadebo BM , Wilson B , Jurkovitz C , Horton T . Alcohol withdrawal rates in hospitalized patients during the COVID-19 pandemic. JAMA Netw Open. 2021;4(3):e210422. doi:10.1001/jamanetworkopen.2021.0422 PubMed Google Scholar

Asrani SK , Trotter J , Lake J , et al. Meeting report: the Dallas Consensus Conference on liver transplantation for alcohol associated hepatitis. Liver Transpl. 2020;26(1):127-140. doi:10.1002/lt.25681 PubMed Google Scholar Crossref

Masters GA , Asipenko E , Bergman AL , et al. Impact of the COVID-19 pandemic on mental health, access to care, and health disparities in the perinatal period. J Psychiatr Res. 2021;137:126-130. doi:10.1016/j.jpsychires.2021.02.056 PubMed Google Scholar Crossref

United Network for Organ Sharing. Liver policy updates: new national liver and intestinal organ transplant system in effect Feb. 4, 2020. Accessed May 17, 2021. https://unos.org/policy/liver-policy-updates/

Lee BP , Im GY , Rice JP , et al. Underestimation of liver transplantation for alcoholic hepatitis in the National Transplant Database. Liver Transpl. 2019;25(5):706-711. doi:10.1002/lt.25448 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.