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Confronting the Delta Variant of SARS-CoV-2, Summer 2021

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Availability of safe and highly effective SARS-CoV-2 vaccines increased the possibility of durable control of COVID-19 both in the US and worldwide. After initial challenges in vaccine supply and delivery, there was substantial progress in vaccinating US residents. The arrival of spring 2021 and increasing vaccination rates, particularly among individuals at high risk for severe infection and complications, was followed by a steady decline in cases, hospitalizations, and deaths.

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, FOB Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: August 18, 2021. doi:10.1001/jama.2021.14811

Conflict of Interest Disclosures: Dr del Rio reported receiving grants from the NIH/NIAID Emory Vaccine and Treatment Evaluation Unit. No other disclosures were reported.

References
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Centers for Disease Control and Prevention. COVID Data Tracker. Accessed August 15, 2021. https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-total-admin-rate-total
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Lauring  AS , Malani  PN .  Variants of SARS-CoV-2.   JAMA. Published online August 13, 2021. doi:10.1001/jama.2021.14181PubMedGoogle Scholar
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Walensky  RP , Walke  HT , Fauci  AS .  SARS-CoV-2 variants of concern in the United States.   JAMA. 2021;325(11):1037-1038. doi:10.1001/jama.2021.2294PubMedGoogle ScholarCrossref
4.
Lopez Bernal  J , Andrews  N , Gower  C ,  et al.  Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant.   N Engl J Med. 2021;385(7):585-594. doi:10.1056/NEJMoa2108891PubMedGoogle ScholarCrossref
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Genomeweb. Study finds J&J vaccine effective against Delta. August 9, 2021. https://www.genomeweb.com/scan/study-finds-jj-vaccine-effective-against-delta#.YRkmPIhKiF5
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Hall  VG , Ferreira  VH , Ku  T ,  et al.  Randomized trial of a third dose of mRNA-1273 vaccine in transplant recipients.   N Engl J Med. Published online August 11, 2021. doi:10.1056/NEJMc2111462PubMedGoogle Scholar
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COVID-19 vaccines for moderately to severely immunocompromised people. CDC. August 16, 2021. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommenda.tions/immuno.html
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Fine  P , Eames  K , Heymann  DL .  “Herd immunity”: a rough guide.   Clin Infect Dis. 2011;52(7):911-916.PubMedGoogle ScholarCrossref
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Diaz C. What Iceland’s rising Covid-19 case count tells us about vaccine efficacy. Quartz. August 8, 2021. Accessed August 15, 2021. https://qz.com/2044284/icelands-rising-covid-19-cases-demonstrate-vaccine-efficacy/
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Omer  SB , Betsch  C , Leask  J . Mandate vaccination with care. Nature. July 22, 2019. Accessed August 15, 2021. https://www.nature.com/articles/d41586-019-02232-0
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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