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Herd immunity is needed to reduce deaths, prevent transmission, and minimize the emergence of SARS-CoV-2 variants. The durability of serum antibodies against the spike protein of this virus provides insights into immunologic memory following natural infection.1 Recent literature supports that the levels of spike antibodies induced by natural infection correlate with neutralization and protect against subsequent infection.2 We evaluated the durability of naturally acquired spike immunoglobin (Ig) G antibodies to SARS-CoV-2 among a cohort of health care workers.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: June 27, 2021.
Published: August 30, 2021. doi:10.1001/jamanetworkopen.2021.23256
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Egbert ER et al. JAMA Network Open.
Corresponding Author: Amanda K. Debes, PhD, MS, Department of International Health, 615 N Wolfe St, E5036, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 (firstname.lastname@example.org).
Author Contributions: Dr Milstone had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Egbert, Milstone, Debes.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Egbert, Colantuoni, Debes.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Xiao, Colantuoni, Debes.
Obtained funding: Milstone.
Administrative, technical, or material support: Egbert, Caturegli, Gadala, Debes.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported through the generosity of the collective community of donors to the Johns Hopkins University School of Medicine and the Johns Hopkins Health System for COVID research. Research reported in this publication was also supported in part by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number K24AI141580 (Dr Milstone).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Additional Contributions: The authors would like to thank members of the Johns Hopkins Hospital Clinical Immunology Laboratory, Danielle Koontz, MA, MS, and Annie Voskertchian, MPH, of the Johns Hopkins Division of Pediatric Infectious Diseases. Contributors received no additional compensation.
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