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Rate of Recurrent Guillain-Barré Syndrome After mRNA COVID-19 Vaccine BNT162b2

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

On December 20, 2020, Israel initiated a national vaccination program against COVID-19. National and international vaccine guidelines did not preclude patients who have previously been diagnosed with Guillain-Barré Syndrome (GBS) from receiving the COVID-19 vaccine.1,2 However, previous association between vaccines and GBS raises the level of caution and hesitancy among clinicians and patients regarding administering the vaccine.35 The aim of this study was to establish rates of GBS relapse among Pfizer-BioNTech BNT162b2 vaccine receivers.

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Article Information

Accepted for Publication: August 5, 2021.

Published Online: September 1, 2021. doi:10.1001/jamaneurol.2021.3287

Corresponding Author: Shirley Shapiro Ben David, MD, Maccabi Healthcare Services, Hamered 27, Tel Aviv 6812509, Israel (shirley.shap@gmail.com).

Author Contributions: Dr Shapiro Ben David had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Shapiro Ben David.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: All authors.

Critical revision of the manuscript for important intellectual content: Rahamim-Cohen.

Supervision: Rahamim-Cohen.

Conflict of Interest Disclosures: None reported.

References
1.
Israeli Ministry of Health. Coronavirus (COVID-19) vaccines. Accessed April 30, 2021. https://www.health.gov.il/UnitsOffice/HD/PH/epidemiology/td/docs/365_Corona.pdff.
2.
Centers for Disease Control and Prevention. COVID-19 vaccines for people with underlying medical conditions. Accessed April 27, 2021. https://www.cdc.gov/coronavirus/2019-ancov/vaccines/recommendations/underlying-conditions.html.
3.
Vellozzi  C , Iqbal  S , Broder  K .  Guillain-Barre syndrome, influenza, and influenza vaccination: the epidemiologic evidence.   Clin Infect Dis. 2014;58(8):1149-1155. doi:10.1093/cid/ciu005PubMedGoogle ScholarCrossref
4.
Martín Arias  LH , Sanz  R , Sáinz  M , Treceño  C , Carvajal  A .  Guillain-Barré syndrome and influenza vaccines: a meta-analysis.   Vaccine. 2015;33(31):3773-3778. doi:10.1016/j.vaccine.2015.05.013PubMedGoogle ScholarCrossref
5.
Lunn  MP , Cornblath  DR , Jacobs  BC ,  et al.  COVID-19 vaccine and Guillain-Barré syndrome: let’s not leap to associations.   Brain. 2021;144(2):357-360. doi:10.1093/brain/awaa444PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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