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Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273

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Article Information

Corresponding Author: Deborah Steensels, PharmD, PhD, Department of Laboratory Medicine, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium (Deborah.steensels@zol.be).

Accepted for Publication: August 19, 2021.

Published Online: August 30, 2021. doi:10.1001/jama.2021.15125

Author Contributions: Drs Steensels and Heylen had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Steensels, Penders, Mesotten, Heylen.

Acquisition, analysis, or interpretation of data: Steensels, Pierlet, Penders, Heylen.

Drafting of the manuscript: Steensels, Heylen.

Critical revision of the manuscript for important intellectual content: Pierlet, Penders, Mesotten, Heylen.

Statistical analysis: Steensels, Pierlet, Heylen.

Obtained funding: Steensels, Penders, Mesotten.

Administrative, technical, or material support: Steensels, Penders, Mesotten.

Supervision: Steensels, Penders.

Conflict of Interest Disclosures: None reported.

Funding/Support: Roche Diagnostics International Ltd provided test reagents and Interreg Euregio Meuse-Rhine provided financial support (grant EMR-187 CODAP).

Role of the Funder/Sponsor: Funders were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

Additional Contributions: We thank Maarten Coemans, MSc, PhD (Leuven Biostatistics Centre, KU Leuven), for his statistical advice. He was not compensated for his contribution.

References
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Khoury  DS , Cromer  D , Reynaldi  A ,  et al.  Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.   Nat Med. 2021;27(7):1205-1211. doi:10.1038/s41591-021-01377-8PubMedGoogle ScholarCrossref
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Rubio-Acero  R , Castelletti  N , Fingerle  V ,  et al; KoCo19 study team.  In search of the SARS-CoV-2 protection correlate: head-to-head comparison of two quantitative S1 assays in pre-characterized oligo-/asymptomatic patients.   Infect Dis Ther. 2021;10(3):1505-1518. doi:10.1007/s40121-021-00475-xPubMedGoogle ScholarCrossref
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Levine-Tiefenbrun  M , Yelin  I , Katz  R ,  et al.  Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine.   Nat Med. 2021;27(5):790-792. doi:10.1038/s41591-021-01316-7PubMedGoogle ScholarCrossref
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