Corresponding Author: Wanda Phipatanakul, MD, MS, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115 (wanda.phipatanakul@childrens.harvard.edu).
Accepted for Publication: June 27, 2021.
Author Contributions: Drs Phipatanakul and Coull had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Phipatanakul, Koutrakis, Coull, Petty, Sheehan, Samnaliev, Baxi, Hauptman, Adamkiewicz, Baccarelli, Gold.
Acquisition, analysis, or interpretation of data: Phipatanakul, Coull, Petty, Gaffin, Sheehan, Lai, Bartnikas, Kang, Wolfson, Samnaliev, Cunningham, Baxi, Permaul, Hauptman, Trivedi, Louisias, Liang, Thorne, Metwali, Israel, Baccarelli, Gold.
Drafting of the manuscript: Phipatanakul, Coull, Petty, Sheehan, Bartnikas, Kang, Baxi, Metwali.
Critical revision of the manuscript for important intellectual content: Phipatanakul, Koutrakis, Coull, Petty, Gaffin, Sheehan, Lai, Bartnikas, Wolfson, Samnaliev, Cunningham, Baxi, Permaul, Hauptman, Trivedi, Louisias, Liang, Thorne, Adamkiewicz, Israel, Baccarelli, Gold.
Statistical analysis: Phipatanakul, Coull, Petty, Sheehan, Lai, Hauptman, Liang, Israel.
Obtained funding: Phipatanakul, Liang, Gold.
Administrative, technical, or material support: Phipatanakul, Kang, Cunningham, Baxi, Permaul, Trivedi, Louisias, Thorne, Metwali.
Supervision: Phipatanakul, Koutrakis, Coull, Gaffin, Wolfson, Cunningham, Baxi, Louisias, Adamkiewicz.
Conflict of Interest Disclosures: Dr Phipatanakul reported receiving nonfinancial support from Coway Co Ltd (provided HEPA filter intervention), ALK-Abelló (provided skin testing reagents), and Monaghen (provided aerochambers); receiving grants from Thermo Fisher and the National Institutes of Health; receiving consulting fees from Genentech/Novartis, Regeneron/Sanofi, and GlaxoSmithKline; receiving funding, clinical trial support, and medications from Genentech/Novartis, Regeneron/Sanofi, and GlaxoSmithKline; and receiving clinical trial medication support from Bohringer Ingelheim, AstraZeneca, Merck, and CSL Behring. Dr Coull reported receiving grants from Apple Inc. Dr Sheehan reported receiving consulting fees from GlaxoSmithKline for serving on an advisory board. Dr Louisias reported receiving grants from the Brigham and Women’s Hospital Nesson Fellowship. Dr Israel reported receiving personal fees from the National Asthma Education and Prevention Program for serving on the coordinating committee, which advises on the asthma guidelines for the US. No other disclosures were reported.
Funding/Support: Coway Co Ltd provided the HEPA filter purifiers. Other in-kind materials were provided by ALK-Abelló, Lincoln Diagnostics, and Thermo Fisher Scientific. This study was supported by grants 5K12HS022986-03, 8UL1TR000170, P30ES031663, P30ES000002, K23ES023700, K23AI104780, K23AI106945, K23AI123517, K23AI143962, K24AI106822, K23HL150341, L30HL143781, P30ES005605, and U01AI110397 from the National Institutes of Health. Additional support was provided by grants DW-75-95877701, NU61TS000296, RD-834798, and RD-835872 from the US Environmental Protection Agency. This work also was supported by the Harvard Catalyst/Harvard Clinical and Translational Science Center and Harvard University and its affiliated academic health care centers.
Role of the Funder/Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The members of the School Inner-City Asthma Intervention study team appear in Supplement 3.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the Harvard Catalyst/Harvard Clinical and Translational Science Center, Harvard University and its affiliated academic health care centers, the National Center for Research Resources, or the National Institutes of Health. In addition, the US Environmental Protection Agency does not endorse the purchase of any commercial products or services mentioned in the publication.
Data Sharing Statement: See Supplement 4.
Additional Contributions: We thank the pest management teams from Buono Pest Control Co Inc and the pest management consultants, Rivard’s Resources, who received compensation for their services. We also thank the participating schools, the students, and their families for the support they provided for the study. This study was additionally monitored by independent monitors at Pharmaceutical Product Development LLC.
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