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Seronegative Chronic Hepatitis C Virus InfectionA Teachable Moment

Educational Objective
To describe the characteristics and appropriate evaluation of patients with seronegative chronic hepatitis C virus (HCV) infection.
1 Credit CME

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Article Information

Corresponding Author: Joshua F. Craft, MD, Department of Internal Medicine and Pediatrics, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD 21201 (jcraft@som.umaryland.edu).

Published Online: September 13, 2021. doi:10.1001/jamainternmed.2021.5182

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
1.
Centers for Disease Control and Prevention. Viral hepatitis surveillance report 2018—hepatitis C. Published July 2020. Accessed March 27, 2021. https://www.cdc.gov/hepatitis/statistics/2018surveillance/HepC.htm
2.
Colin  C , Lanoir  D , Touzet  S , Meyaud-Kraemer  L , Bailly  F , Trepo  C ; HEPATITIS Group.  Sensitivity and specificity of third-generation hepatitis C virus antibody detection assays: an analysis of the literature.   J Viral Hepat. 2001;8(2):87-95. doi:10.1046/j.1365-2893.2001.00280.xPubMedGoogle ScholarCrossref
3.
Chamie  G , Bonacini  M , Bangsberg  DR ,  et al.  Factors associated with seronegative chronic hepatitis C virus infection in HIV infection.   Clin Infect Dis. 2007;44(4):577-583. doi:10.1086/511038PubMedGoogle ScholarCrossref
4.
Jadoul  M , Berenguer  MC , Doss  W ,  et al.  Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management.   Kidney Int. 2018;94(4):663-673. doi:10.1016/j.kint.2018.06.011PubMedGoogle ScholarCrossref
5.
Alter  MJ , Margolis  HS , Krawczynski  K ,  et al.  The natural history of community-acquired hepatitis C in the United States. the Sentinel Counties Chronic non-A, non-B Hepatitis Study Team.   N Engl J Med. 1992;327(27):1899-1905. doi:10.1056/NEJM199212313272702PubMedGoogle ScholarCrossref
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