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Trends in Outpatient Antibiotic Prescriptions in the United States During the COVID-19 Pandemic in 2020

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Article Information

Accepted for Publication: July 19, 2021.

Published: September 22, 2021. doi:10.1001/jamanetworkopen.2021.26114

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Buehrle DJ et al. JAMA Network Open.

Corresponding Author: Cornelius J. Clancy, MD, VA Pittsburgh Healthcare System, 3550 Terrace St, Scaife Hall 867, Pittsburgh, PA 15261 (cjc76@pitt.edu).

Author Contributions: Dr Clancy and Dr Buehrle had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Buehrle, Nguyen, Clancy.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Buehrle, Clancy.

Critical revision of the manuscript for important intellectual content: Buehrle, Wagener, Nguyen.

Statistical analysis: Wagener, Nguyen, Clancy.

Supervision: Buehrle, Clancy.

Conflict of Interest Disclosures: Dr Nguyen reported receiving grants from Astellas, Merck, Melinta, and Cidara outside the submitted work and reported serving on advisory boards for Astellas, Merck, the Medicines Company, Scynexis, and Shionogi. Dr Clancy reported receiving grants from Astellas, Merck, Melinta, and Cidara outside the submitted work, serving on advisory boards or consulting for Astellas, Merck, the Medicines Company, Cidara, Scynexis, Shionogi, Qpex, and Needham and Company, and being a speaker at a symposium sponsored by Merck and T2Biosystems. Dr Buehrle reported serving on an advisory board for Shionogi outside the submitted work. No other disclosures were reported.

Additional Contributions: The authors thank Alan Carr, PhD (Needham and Company) for his assistance with obtaining and interpreting IQVIA National Prescription Audit data. Dr Carr did not receive compensation.

References
1.
Buehrle  DJ , Nguyen  MH , Wagener  MM , Clancy  CJ .  Impact of the coronavirus disease 2019 pandemic on outpatient antibiotic prescriptions in the United States.  [published online December 22, 2020].  Open Forum Infect Dis. 2020;7(12):a575. doi:10.1093/ofid/ofaa575 PubMedGoogle ScholarCrossref
2.
Buehrle  DJ , Wagener  MM , Clancy  CJ .  Outpatient fluoroquinolone prescription fills in the United States, 2014 to 2020: assessing the impact of Food and Drug Administration safety warnings.   Antimicrob Agents Chemother. 2021;65(7):e0015121. doi:10.1128/AAC.00151-21 PubMedGoogle Scholar
3.
Tran  PT , Antonelli  PJ , Hincapie-Castillo  JM , Winterstein  AG .  Association of US Food and Drug Administration removal of indications for use of oral quinolones with prescribing trends.  [published online April 19, 2021].  JAMA Intern Med. 2021;181(6):808-816. doi:10.1001/jamainternmed.2021.1154 PubMedGoogle ScholarCrossref
4.
Centers for Disease Control and Prevention. Reduced Access to Care: Household Pulse Survey. https://www.cdc.gov/nchs/covid19/pulse/reduced-access-to-care.htm. Accessed April 22, 2021.
5.
Metlay  JP , Waterer  GW , Long  AC ,  et al.  Diagnosis and treatment of adults with community-acquired pneumonia. an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America.   Am J Respir Crit Care Med. 2019;200(7):e45-e67. doi:10.1164/rccm.201908-1581ST PubMedGoogle ScholarCrossref
6.
Centers for Disease Control and Prevention. Weekly U.S. Influenza Surveillance Report. Accessed April 22, 2021. https://www.cdc.gov/flu/weekly/index.htm.
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