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Schizophrenia spectrum disorders are associated with increased mortality in the setting of COVID-19 infection.1- 3 Among several possible explanations for this increased risk is the role of adverse effects of antipsychotic medication, which has not been systematically examined in this population. Our goal was to investigate whether antecedent antipsychotic use was associated with mortality among patients with serious mental illness diagnosed with COVID-19.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: July 19, 2021.
Published Online: September 22, 2021. doi:10.1001/jamapsychiatry.2021.2503
Corresponding Author: Donald C. Goff, MD, Department of Psychiatry, New York University Langone Medical Center, One Park Avenue, New York, NY 10016 (firstname.lastname@example.org).
Author Contributions: Drs Nemani and Goff had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Nemani, Thorpe, Goff.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Nemani, Marx.
Critical revision of the manuscript for important intellectual content: Nemani, Conderino, Thorpe, Goff.
Statistical analysis: Nemani, Conderino, Thorpe.
Administrative, technical, or material support: Marx, Goff.
Supervision: Nemani, Thorpe, Goff.
Conflict of Interest Disclosures: None reported.
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