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Association Between Antipsychotic Use and COVID-19 Mortality Among People With Serious Mental Illness

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Schizophrenia spectrum disorders are associated with increased mortality in the setting of COVID-19 infection.13 Among several possible explanations for this increased risk is the role of adverse effects of antipsychotic medication, which has not been systematically examined in this population. Our goal was to investigate whether antecedent antipsychotic use was associated with mortality among patients with serious mental illness diagnosed with COVID-19.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: July 19, 2021.

Published Online: September 22, 2021. doi:10.1001/jamapsychiatry.2021.2503

Corresponding Author: Donald C. Goff, MD, Department of Psychiatry, New York University Langone Medical Center, One Park Avenue, New York, NY 10016 (donald.goff@nyulangone.org).

Author Contributions: Drs Nemani and Goff had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Nemani, Thorpe, Goff.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Nemani, Marx.

Critical revision of the manuscript for important intellectual content: Nemani, Conderino, Thorpe, Goff.

Statistical analysis: Nemani, Conderino, Thorpe.

Administrative, technical, or material support: Marx, Goff.

Supervision: Nemani, Thorpe, Goff.

Conflict of Interest Disclosures: None reported.

References
1.
Nemani  K , Li  C , Olfson  M ,  et al.  Association of psychiatric disorders with mortality among patients with COVID-19.   JAMA Psychiatry. 2021;78(4):380-386. doi:10.1001/jamapsychiatry.2020.4442PubMedGoogle ScholarCrossref
2.
Bulletin  S , Tzur Bitan  D , Krieger  I ,  et al.  COVID-19 prevalence and mortality among schizophrenia patients: a large-scale retrospective cohort study.   Schizophr Bull. Published online February 19, 2021. doi:10.1093/schbul/sbab012Google Scholar
3.
Fond  G , Pauly  V , Leone  M ,  et al.  Disparities in intensive care unit admission and mortality among patients with schizophrenia and COVID-19: a national cohort study.   Schizophr Bull. 2021;47(3):624-634. doi:10.1093/schbul/sbaa158PubMedGoogle ScholarCrossref
4.
Walker  ER , McGee  RE , Druss  BG .  Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.   JAMA Psychiatry. 2015;72(4):334-341. doi:10.1001/jamapsychiatry.2014.2502PubMedGoogle ScholarCrossref
5.
Reilev  M , Kristensen  KB , Pottegård  A ,  et al.  Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.   Int J Epidemiol. 2020;49(5):1468-1481. doi:10.1093/ije/dyaa140PubMedGoogle ScholarCrossref
6.
Poblador-Plou  B , Carmona-Pírez  J , Ioakeim-Skoufa  I ,  et al; EpiChron Group.  Baseline chronic comorbidity and mortality in laboratory-confirmed COVID-19 cases: results from the PRECOVID study in Spain.   Int J Environ Res Public Health. 2020;17(14):1-14. doi:10.3390/ijerph17145171PubMedGoogle ScholarCrossref
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