Quiz

Clinical Challenge

Rapidly Enlarging Neck Mass in a Patient With Testicular Cancer

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.

1 Credit CME

JAMA Otolaryngology–Head & Neck Surgery

November 1, 2021

Clinical Challenge

Article Information and Disclosures

Gopikrishna M. Rao, BS¹;

Jennifer L. Harb, MD²;

Jeremiah C. Tracy, MD²

Author Affiliations

¹Tufts University School of Medicine, Boston, Massachusetts
²Department of Otolaryngology–Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts

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Article Information

Corresponding Author: Jeremiah C. Tracy, MD, Department of Otolaryngology–Head and Neck Surgery, Tufts Medical Center, 800 Washington St, Box 850, Boston, MA 02111 (jtracy@tuftsmedicalcenter.org).

Published Online: September 23, 2021. doi:10.1001/jamaoto.2021.2420

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References

Logothetis CJ , Samuels ML , Trindade A , Johnson DE . The growing teratoma syndrome. Cancer. 1982;50(8):1629-1635. doi:10.1002/1097-0142(19821015)50:8<1629::AID-CNCR2820500828>3.0.CO;2-1 PubMed Google Scholar Crossref

Lee DJ , Djaladat H , Tadros NN , et al. Growing teratoma syndrome: clinical and radiographic characteristics. Int J Urol. 2014;21(9):905-908. doi:10.1111/iju.12466 PubMed Google Scholar Crossref

Nimkin K , Gupta P , McCauley R , Gilchrist BF , Lessin MS . The growing teratoma syndrome. Pediatr Radiol. 2004;34(3):259-262. doi:10.1007/s00247-003-1045-z PubMed Google Scholar Crossref

Nassiri N , Shah A , Daneshmand S . Growing teratoma syndrome of testicular origin. Urology. 2019;123:20-23. doi:10.1016/j.urology.2018.05.015 PubMed Google Scholar Crossref

Hiester A , Nettersheim D , Nini A , Lusch A , Albers P . Management, treatment, and molecular background of the growing teratoma syndrome. Urol Clin North Am. 2019;46(3):419-427. doi:10.1016/j.ucl.2019.04.008 PubMed Google Scholar Crossref

Laguna M , Albers P , Algaba F , et al. EAU guidelines on testicular cancer. Accessed August 17, 2021. https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Testicular-Cancer-2020.pdf

Kesler KA , Patel JB , Kruter LE , et al. The “growing teratoma syndrome” in primary mediastinal nonseminomatous germ cell tumors: criteria based on current practice. J Thorac Cardiovasc Surg. 2012;144(2):438-443. doi:10.1016/j.jtcvs.2012.05.053 PubMed Google Scholar Crossref

André F , Fizazi K , Culine S , et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36(11):1389-1394. doi:10.1016/S0959-8049(00)00137-4 PubMed Google Scholar Crossref

Motzer RJ , Amsterdam A , Prieto V , et al. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol. 1998;159(1):133-138. doi:10.1016/S0022-5347(01)64035-7 PubMed Google Scholar Crossref

10.

Jones TD , Wang M , Sung MT , et al. Clonal origin of metastatic testicular teratomas. Clin Cancer Res. 2006;12(18):5377-5383. doi:10.1158/1078-0432.CCR-06-0444 PubMed Google Scholar Crossref

Rapidly Enlarging Neck Mass in a Patient With Testicular Cancer

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Rapidly Enlarging Neck Mass in a Patient With Testicular Cancer

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