[Skip to Content]
[Skip to Content Landing]

Eosinophilic EsophagitisA Review

Educational Objective
To review the diagnosis and treatment of eosinophilic esophagitis.
1 Credit CME

Importance  Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and North America. EoE affects both children and adults, and causes dysphagia, food impaction of the esophagus, and esophageal strictures.

Observations  EoE is defined by symptoms of esophageal dysfunction, such as vomiting, dysphagia, or feeding difficulties, in a patient with an esophageal biopsy demonstrating at least 15 eosinophils per high-power field in the absence of other conditions associated with esophageal eosinophilia such as gastroesophageal reflux disease or achalasia. Genetic factors and environmental factors, such as exposure to antibiotics early in life, are associated with EoE. Current therapies include proton pump inhibitors; topical steroid preparations, such as fluticasone and budesonide; dietary therapy with amino acid formula or empirical food elimination; and endoscopic dilation. In a systematic review of observational studies that included 1051 patients with EoE, proton pump inhibitor therapy was associated with a histologic response, defined as less than 15 eosinophils per high-power field on endoscopic biopsy, in 41.7% of patients, while placebo was associated with a 13.3% response rate. In a systematic review of 8 randomized trials of 437 patients with EoE, topical corticosteroid treatment was associated with histologic remission in 64.9% of patients compared with 13.3% for placebo. Patients with esophageal narrowing may require dilation. Objective assessment of therapeutic response typically requires endoscopy with biopsy.

Conclusions and Relevance  EoE has a prevalence of approximately 34.4/100 000 worldwide. Treatments consist of proton pump inhibitors, topical steroids, elemental diet, and empirical food elimination, with esophageal dilation reserved for patients with symptomatic esophageal narrowing.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Gary W. Falk, MD, MS, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, 7th Floor, South Pavilion, Philadelphia, PA 19104 (gary.falk@pennmedicine.upenn.edu).

Accepted for Publication: August 17, 2021.

Author Contributions: Drs Muir and Falk had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Both authors.

Acquisition, analysis, or interpretation of data: Both authors.

Drafting of the manuscript: Both authors.

Critical revision of the manuscript for important intellectual content: Both authors.

Administrative, technical, or material support: Both authors.

Conflict of Interest Disclosures: Dr Muir reported receiving research funding from Allakos. Dr Falk reported receiving research funding from Allakos, Arena, Adare/Ellodi, Bristol Myers Squibb, Celgene, Lucid, Regeneron, and Shire/Takeda and is a consultant for Allakos, Adare/Ellodi, Bristol Myers Squibb/Celgene, Lucid, Sanofi, and Shire/Takeda.

Funding/Support: This work was supported in part by the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Center for Molecular Studies in Digestive and Liver Disease (P30DK050306) and by the Consortium for Eosinophilic Gastrointestinal Disease Research (CEGIR) (U54 AI117804), which is part of the Rare Disease Clinical Research Network (RDCRN), an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Sciences (NCATS), and is funded through collaboration between the National Institute of Allergy and Infectious Diseases, NIDDK, and NCATS. CEGIR is also supported by patient advocacy groups including the American Partnership for Eosinophilic Disorders, Campaign Urging Research for Eosinophilic Diseases, and Eosinophilic Family Coalition. As a member of the RDCRN, CEGIR is also supported by its data management and coordinating center (U2CTR002818). Dr Muir is funded by NIH grants R01 DK124266-01 and R21TR00303902.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Dellon  ES , Hirano  I .  Epidemiology and natural history of eosinophilic esophagitis.   Gastroenterology. 2018;154(2):319-332.e3. doi:10.1053/j.gastro.2017.06.067 PubMedGoogle ScholarCrossref
Navarro  P , Arias  Á , Arias-González  L , Laserna-Mendieta  EJ , Ruiz-Ponce  M , Lucendo  AJ .  Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies.   Aliment Pharmacol Ther. 2019;49(9):1116-1125. doi:10.1111/apt.15231 PubMedGoogle ScholarCrossref
Dellon  ES , Liacouras  CA , Molina-Infante  J ,  et al.  Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE Conference.   Gastroenterology. 2018;155(4):1022-1033.e10. doi:10.1053/j.gastro.2018.07.009 PubMedGoogle ScholarCrossref
Thomsen  SF .  Epidemiology and natural history of atopic diseases.   Eur Clin Respir J. 2015;2(1):24642. doi:10.3402/ecrj.v2.24642 PubMedGoogle ScholarCrossref
Noti  M , Wojno  EDT , Kim  BS ,  et al.  Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.   Nat Med. 2013;19(8):1005-1013. doi:10.1038/nm.3281 PubMedGoogle ScholarCrossref
Aceves  SS , Chen  D , Newbury  RO , Dohil  R , Bastian  JF , Broide  DH .  Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction.   J Allergy Clin Immunol. 2010;126(6):1198-204.e4. doi:10.1016/j.jaci.2010.08.050 PubMedGoogle ScholarCrossref
Alexander  ES , Martin  LJ , Collins  MH ,  et al.  Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.   J Allergy Clin Immunol. 2014;134(5):1084-1092.e1. doi:10.1016/j.jaci.2014.07.021 PubMedGoogle ScholarCrossref
Rothenberg  ME , Spergel  JM , Sherrill  JD ,  et al.  Common variants at 5q22 associate with pediatric eosinophilic esophagitis.   Nat Genet. 2010;42(4):289-291. doi:10.1038/ng.547 PubMedGoogle ScholarCrossref
Sleiman  PMA , Wang  ML , Cianferoni  A ,  et al.  GWAS identifies four novel eosinophilic esophagitis loci.   Nat Commun. 2014;5:5593. doi:10.1038/ncomms6593 PubMedGoogle ScholarCrossref
Sherrill  JD , Rothenberg  ME .  Genetic and epigenetic underpinnings of eosinophilic esophagitis.   Gastroenterol Clin North Am. 2014;43(2):269-280. doi:10.1016/j.gtc.2014.02.003 PubMedGoogle ScholarCrossref
Kottyan  LC , Parameswaran  S , Weirauch  MT , Rothenberg  ME , Martin  LJ .  The genetic etiology of eosinophilic esophagitis.   J Allergy Clin Immunol. 2020;145(1):9-15. doi:10.1016/j.jaci.2019.11.013 PubMedGoogle ScholarCrossref
Jensen  ET , Dellon  ES .  Environmental factors and eosinophilic esophagitis.   J Allergy Clin Immunol. 2018;142(1):32-40. doi:10.1016/j.jaci.2018.04.015 PubMedGoogle ScholarCrossref
Muir  AB , Benitez  AJ , Dods  K , Spergel  JM , Fillon  SA .  Microbiome and its impact on gastrointestinal atopy.   Allergy. 2016;71(9):1256-1263. doi:10.1111/all.12943 PubMedGoogle ScholarCrossref
Dellon  ES , Gibbs  WB , Fritchie  KJ ,  et al.  Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease.   Clin Gastroenterol Hepatol. 2009;7(12):1305-1313. doi:10.1016/j.cgh.2009.08.030 PubMedGoogle ScholarCrossref
Hiremath  GS , Hameed  F , Pacheco  A , Olive  A , Davis  CM , Shulman  RJ .  Esophageal food impaction and eosinophilic esophagitis: a retrospective study, systematic review, and meta-analysis.   Dig Dis Sci. 2015;60(11):3181-3193. doi:10.1007/s10620-015-3723-8 PubMedGoogle ScholarCrossref
Chang  JW , Olson  S , Kim  JY ,  et al.  Loss to follow-up after food impaction among patients with and without eosinophilic esophagitis.   Dis Esophagus. 2019;32(12):1-4. doi:10.1093/dote/doz056 PubMedGoogle Scholar
Schoepfer  AM , Safroneeva  E , Bussmann  C ,  et al.  Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner.   Gastroenterology. 2013;145(6):1230-6.e1, 2. doi:10.1053/j.gastro.2013.08.015 PubMedGoogle ScholarCrossref
Warners  MJ , Oude Nijhuis  RAB , de Wijkerslooth  LRH , Smout  AJPM , Bredenoord  AJ .  The natural course of eosinophilic esophagitis and long-term consequences of undiagnosed disease in a large cohort.   Am J Gastroenterol. 2018;113(6):836-844. doi:10.1038/s41395-018-0052-5PubMedGoogle ScholarCrossref
Hirano  I , Moy  N , Heckman  MG , Thomas  CS , Gonsalves  N , Achem  SR .  Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system.   Gut. 2013;62(4):489-495. doi:10.1136/gutjnl-2011-301817 PubMedGoogle ScholarCrossref
Dellon  ES , Gonsalves  N , Hirano  I , Furuta  GT , Liacouras  CA , Katzka  DA ; American College of Gastroenterology.  ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE).   Am J Gastroenterol. 2013;108(5):679-692. doi:10.1038/ajg.2013.71 PubMedGoogle ScholarCrossref
Dellon  ES , Speck  O , Woodward  K ,  et al.  Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy.   Mod Pathol. 2015;28(3):383-390. doi:10.1038/modpathol.2014.110 PubMedGoogle ScholarCrossref
Safroneeva  E , Straumann  A , Coslovsky  M ,  et al; International Eosinophilic Esophagitis Activity Index Study Group.  Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis.   Gastroenterology. 2016;150(3):581-590.e4. doi:10.1053/j.gastro.2015.11.004 PubMedGoogle ScholarCrossref
Katzka  DA , Smyrk  TC , Alexander  JA ,  et al.  Accuracy and safety of the cytosponge for assessing histologic activity in eosinophilic esophagitis: a two-center study.   Am J Gastroenterol. 2017;112(10):1538-1544. doi:10.1038/ajg.2017.244 PubMedGoogle ScholarCrossref
Ackerman  SJ , Kagalwalla  AF , Hirano  I ,  et al.  One-hour esophageal string test: a nonendoscopic minimally invasive test that accurately detects disease activity in eosinophilic esophagitis.   Am J Gastroenterol. 2019;114(10):1614-1625. doi:10.14309/ajg.0000000000000371 PubMedGoogle ScholarCrossref
Nguyen  N , Lavery  WJ , Capocelli  KE ,  et al.  Transnasal endoscopy in unsedated children with eosinophilic esophagitis using virtual reality video goggles.   Clin Gastroenterol Hepatol. 2019;17(12):2455-2462. doi:10.1016/j.cgh.2019.01.023 PubMedGoogle ScholarCrossref
Wen  T , Rothenberg  ME .  Clinical applications of the eosinophilic esophagitis diagnostic panel.   Front Med (Lausanne). 2017;4(JUL):108. doi:10.3389/fmed.2017.00108 PubMedGoogle Scholar
Shoda  T , Wen  T , Aceves  SS ,  et al; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).  Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.   Lancet Gastroenterol Hepatol. 2018;3(7):477-488. doi:10.1016/S2468-1253(18)30096-7 PubMedGoogle ScholarCrossref
Menard-Katcher  C , Benitez  AJ , Pan  Z ,  et al.  Influence of age and eosinophilic esophagitis on esophageal distensibility in a pediatric cohort.   Am J Gastroenterol. 2017;112(9):1466-1473. doi:10.1038/ajg.2017.131 PubMedGoogle ScholarCrossref
Hassan  M , Aceves  S , Dohil  R ,  et al.  Esophageal compliance quantifies epithelial remodeling in pediatric patients with eosinophilic esophagitis.   J Pediatr Gastroenterol Nutr. 2019;68(4):559-565. doi:10.1097/MPG.0000000000002202 PubMedGoogle ScholarCrossref
Carlson  DA , Lin  Z , Hirano  I , Gonsalves  N , Zalewski  A , Pandolfino  JE .  Evaluation of esophageal distensibility in eosinophilic esophagitis: an update and comparison of functional lumen imaging probe analytic methods.   Neurogastroenterol Motil. 2016;28(12):1844-1853. doi:10.1111/nmo.12888 PubMedGoogle ScholarCrossref
Nicodème  F , Hirano  I , Chen  J ,  et al.  Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis.   Clin Gastroenterol Hepatol. 2013;11(9):1101-1107.e1. doi:10.1016/j.cgh.2013.03.020 PubMedGoogle ScholarCrossref
Rank  MA , Sharaf  RN , Furuta  GT ,  et al; AGA Institute; Joint Task Force on Allergy-Immunology Practice Parameters collaborators; AGA Institute; Joint Task Force on Allergy-Immunology Practice Parameters collaborators.  Technical review on the management of eosinophilic esophagitis: a report from the AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters.   Gastroenterology. 2020;158(6):1789-1810.e15. doi:10.1053/j.gastro.2020.02.039 PubMedGoogle ScholarCrossref
Katzka  DA , Kahrilas  PJ .  Advances in the diagnosis and management of gastroesophageal reflux disease.   BMJ. 2020;371:m3786. doi:10.1136/bmj.m3786 PubMedGoogle Scholar
Moayyedi  P , Eikelboom  JW , Bosch  J ,  et al; COMPASS Investigators.  Safety of proton pump inhibitors based on a large, multi-year, randomized trial of patients receiving rivaroxaban or aspirin.   Gastroenterology. 2019;157(3):682-691.e2. doi:10.1053/j.gastro.2019.05.056 PubMedGoogle ScholarCrossref
Vaezi  MF , Yang  YX , Howden  CW .  Complications of proton pump inhibitor therapy.   Gastroenterology. 2017;153(1):35-48. doi:10.1053/j.gastro.2017.04.047 PubMedGoogle ScholarCrossref
Dellon  ES , Woosley  JT , Arrington  A ,  et al.  Efficacy of budesonide vs fluticasone for initial treatment of eosinophilic esophagitis in a randomized controlled trial.   Gastroenterology. 2019;157(1):65-73.e5. doi:10.1053/j.gastro.2019.03.014 PubMedGoogle ScholarCrossref
Chang  JW , Rubenstein  JH , Mellinger  JL ,  et al.  Motivations, barriers, and outcomes of patient-reported shared decision making in eosinophilic esophagitis.   Dig Dis Sci. 2021;66(6):1808-1817. doi:10.1007/s10620-020-06438-5 PubMedGoogle ScholarCrossref
Hirano  I , Chan  ES , Rank  MA ,  et al; AGA Institute Clinical Guidelines Committee; Joint Task Force on Allergy-Immunology Practice Parameters.  AGA Institute and the Joint Task Force on Allergy-Immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis.   Gastroenterology. 2020;158(6):1776-1786. doi:10.1053/j.gastro.2020.02.038 PubMedGoogle ScholarCrossref
Gonsalves  N , Yang  GY , Doerfler  B , Ritz  S , Ditto  AM , Hirano  I .  Elimination diet effectively treats eosinophilic esophagitis in adults: food reintroduction identifies causative factors.   Gastroenterology. 2012;142(7):1451-9.e1. doi:10.1053/j.gastro.2012.03.001 PubMedGoogle ScholarCrossref
Doerfler  B , Bryce  P , Hirano  I , Gonsalves  N .  Practical approach to implementing dietary therapy in adults with eosinophilic esophagitis: the Chicago experience.   Dis Esophagus. 2015;28(1):42-58. doi:10.1111/dote.12175 PubMedGoogle ScholarCrossref
Molina-Infante  J , Bredenoord  AJ , Cheng  E ,  et al; PPI-REE Task Force of the European Society of Eosinophilic Oesophagitis (EUREOS).  Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.   Gut. 2016;65(3):524-531. doi:10.1136/gutjnl-2015-310991 PubMedGoogle ScholarCrossref
Wen  T , Dellon  ES , Moawad  FJ , Furuta  GT , Aceves  SS , Rothenberg  ME .  Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.   J Allergy Clin Immunol. 2015;135(1):187-197. doi:10.1016/j.jaci.2014.08.043 PubMedGoogle ScholarCrossref
Dellon  ES , Speck  O , Woodward  K ,  et al.  Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study.   Am J Gastroenterol. 2013;108(12):1854-1860. doi:10.1038/ajg.2013.363 PubMedGoogle ScholarCrossref
Cheng  E , Zhang  X , Huo  X ,  et al.  Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.   Gut. 2013;62(6):824-832. doi:10.1136/gutjnl-2012-302250 PubMedGoogle ScholarCrossref
Cheng  E , Zhang  X , Wilson  KS ,  et al.  JAK-STAT6 pathway inhibitors block eotaxin-3 secretion by epithelial cells and fibroblasts from esophageal eosinophilia patients: promising agents to improve inflammation and prevent fibrosis in EOE.   PLoS One. 2016;11(6):e0157376. doi:10.1371/journal.pone.0157376 PubMedGoogle Scholar
Lucendo  AJ , Arias  Á , Molina-Infante  J .  Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis.   Clin Gastroenterol Hepatol. 2016;14(1):13-22.e1. doi:10.1016/j.cgh.2015.07.041 PubMedGoogle ScholarCrossref
Laserna-Mendieta  EJ , Casabona  S , Guagnozzi  D ,  et al; EUREOS EoE CONNECT Research group.  Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry.   Aliment Pharmacol Ther. 2020;52(5):798-807. doi:10.1111/apt.15957 PubMedGoogle ScholarCrossref
Freedberg  DE , Kim  LS , Yang  YX .  The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association.   Gastroenterology. 2017;152(4):706-715. doi:10.1053/j.gastro.2017.01.031 PubMedGoogle ScholarCrossref
Lucendo  AJ , Miehlke  S , Schlag  C ,  et al; International EOS-1 Study Group.  Efficacy of budesonide orodispersible tablets as induction therapy for eosinophilic esophagitis in a randomized placebo-controlled trial.   Gastroenterology. 2019;157(1):74-86.e15. doi:10.1053/j.gastro.2019.03.025 PubMedGoogle ScholarCrossref
Philpott  H , Dougherty  MK , Reed  CC ,  et al.  Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis.   Aliment Pharmacol Ther. 2018;47(8):1071-1078. doi:10.1111/apt.14573 PubMedGoogle ScholarCrossref
Hirano  I , Collins  MH , Katzka  DA ,  et al; ORBIT1/SHP621-301 Investigators.  Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial.   Clin Gastroenterol Hepatol. 2021;S1542-3565(21)00456-0. doi:10.1016/j.cgh.2021.04.022PubMedGoogle Scholar
Moawad  FJ , Molina-Infante  J , Lucendo  AJ , Cantrell  SE , Tmanova  L , Douglas  KM .  Systematic review with meta-analysis: endoscopic dilation is highly effective and safe in children and adults with eosinophilic oesophagitis.   Aliment Pharmacol Ther. 2017;46(2):96-105. doi:10.1111/apt.14123 PubMedGoogle ScholarCrossref
Dougherty  M , Runge  TM , Eluri  S , Dellon  ES .  Esophageal dilation with either bougie or balloon technique as a treatment for eosinophilic esophagitis: a systematic review and meta-analysis.   Gastrointest Endosc. 2017;86(4):581-591.e3. doi:10.1016/j.gie.2017.04.028 PubMedGoogle ScholarCrossref
Schoepfer  AM , Gonsalves  N , Bussmann  C ,  et al.  Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation.   Am J Gastroenterol. 2010;105(5):1062-1070. doi:10.1038/ajg.2009.657 PubMedGoogle ScholarCrossref
Runge  TM , Eluri  S , Woosley  JT , Shaheen  NJ , Dellon  ES .  Control of inflammation decreases the need for subsequent esophageal dilation in patients with eosinophilic esophagitis.   Dis Esophagus. 2017;30(7):1-7. doi:10.1093/dote/dox042 PubMedGoogle ScholarCrossref
Straumann  A , Katzka  DA .  Diagnosis and treatment of eosinophilic esophagitis.   Gastroenterology. 2018;154(2):346-359. doi:10.1053/j.gastro.2017.05.066 PubMedGoogle ScholarCrossref
Hirano  I , Furuta  GT .  Approaches and challenges to management of pediatric and adult patients with eosinophilic esophagitis.   Gastroenterology. 2020;158(4):840-851. doi:10.1053/j.gastro.2019.09.052 PubMedGoogle ScholarCrossref
Reed  CC , Tappata  M , Eluri  S , Shaheen  NJ , Dellon  ES .  Combination therapy with elimination diet and corticosteroids is effective for adults with eosinophilic esophagitis.   Clin Gastroenterol Hepatol. 2019;17(13):2800-2802. doi:10.1016/j.cgh.2019.03.009 PubMedGoogle ScholarCrossref
Dellon  ES , Kim  HP , Sperry  SLW , Rybnicek  DA , Woosley  JT , Shaheen  NJ .  A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease.   Gastrointest Endosc. 2014;79(4):577-85.e4. doi:10.1016/j.gie.2013.10.027 PubMedGoogle ScholarCrossref
Dellon  ES , Woosley  JT , Arrington  A ,  et al.  Rapid recurrence of eosinophilic esophagitis activity after successful treatment in the observation phase of a randomized, double-blind, double-dummy trial.   Clin Gastroenterol Hepatol. 2020;18(7):1483-1492.e2. doi:10.1016/j.cgh.2019.08.050 PubMedGoogle ScholarCrossref
Greuter  T , Bussmann  C , Safroneeva  E ,  et al.  Long-term treatment of eosinophilic esophagitis with swallowed topical corticosteroids: development and evaluation of a therapeutic concept.   Am J Gastroenterol. 2017;112(10):1527-1535. doi:10.1038/ajg.2017.202 PubMedGoogle ScholarCrossref
Straumann  A , Conus  S , Degen  L ,  et al.  Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis.   Clin Gastroenterol Hepatol. 2011;9(5):400-9.e1. doi:10.1016/j.cgh.2011.01.017 PubMedGoogle ScholarCrossref
Straumann  A , Lucendo  AJ , Miehlke  S ,  et al; International EOS-2 Study Group.  Budesonide orodispersible tablets maintain remission in a randomized, placebo-controlled trial of patients with eosinophilic esophagitis.   Gastroenterology. 2020;159(5):1672-1685.e5. doi:10.1053/j.gastro.2020.07.039 PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience

Lookup An Activity


My Saved Searches

You currently have no searches saved.


My Saved Courses

You currently have no courses saved.