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Assessment of the Burden of SARS-CoV-2 Variants of Concern Among Essential Workers in the Greater Toronto Area, Canada

Educational Objective
To identify the key insights or developments described in this article
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: July 10, 2021.

Published: October 19, 2021. doi:10.1001/jamanetworkopen.2021.30284

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Chagla Z et al. JAMA Network Open.

Corresponding Author: Zain Chagla, MD, Charlton Ave E, Rm 300-25, Hamilton, ON L5G 3L2, Canada (chaglaz@mcmaster.ca).

Author Contributions: Dr Chagla had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Baral and Mishra contributed equally.

Concept and design: Chagla, Ma, Sander, Baral, Mishra.

Acquisition, analysis, or interpretation of data: Ma, Sander, Baral, Moloney, Mishra.

Drafting of the manuscript: Chagla, Ma, Baral, Mishra.

Critical revision of the manuscript for important intellectual content: Chagla, Ma, Sander, Moloney, Mishra.

Statistical analysis: Chagla, Ma, Baral, Mishra.

Obtained funding: Baral, Mishra.

Administrative, technical, or material support: Ma, Moloney, Mishra.

Supervision: Mishra.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was funded by the Canadian Institutes of Health Research (grant No. VR5-172683).

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Previous Posting: This manuscript was posted as a preprint on medRxiv on March 26, 2021.

Additional Contributions: Reported COVID-19 cases were obtained from the Contact Management Solutions (CCM)+ via the Ontario COVID-19 Modelling Consensus Table and Ontario Ministry of Health. We thank Kristy Yiu, MSc, MAP Centre for Urban Health Solutions, St Michael’s Hospital, for support with data management, and the Ontario Community Health Profiles Partnership. She was not compensated beyond regular salary for this contribution.

References
1.
World Health Organization. Tracking SARS-CoV-2 variants. Accessed July 2, 2021. https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/
2.
Sundaram  M , Calzavara  A , Mishra  S ,  et al  The individual and social determinants of COVID-19 diagnosis in Ontario, Canada: a population-wide study.   medRxiv. Preprint posted online March 21, 2021. doi:10.1101/2020.11.09.20223792Google Scholar
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Rüdiger  S , Plietzsch  A , Sagués  F , Sokolov  IM , Kurths  J .  Epidemics with mutating infectivity on small-world networks.   Sci Rep. 2020;10(1):5919. doi:10.1038/s41598-020-62597-5PubMedGoogle ScholarCrossref
4.
Public Health Ontario. Weekly epidemiologic summary COVID-19 in Ontario: Focus on March 7, 2021 to March 13. Published March 2021. Accessed September 17, 2021. https://files.ontario.ca/moh-covid-19-weekly-epi-report-en-2021-03-13.pdf
5.
Public Health Ontario. SARS-CoV-2 (COVID-19 Virus) variant of concern (VoC) surveillance. Updated March 22, 2021. Accessed September 17, 2021. https://www.publichealthontario.ca/en/laboratory-services/test-information-index/covid-19-voc
6.
Government of Ontario. COVID-19 public health measures and advice. Updated March 19, 2021. Accessed September 17, 2021. https://covid-19.ontario.ca/public-health-measures
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