Clinicians may rely on recommendations from clinical practice guidelines for management of patients.
A clinical practice guideline is a published statement that includes recommendations that are intended to optimize patient care. In the guideline development process, a panel of experts formulates recommendation questions that guide the retrieval of evidence that is used to inform the recommendations. Typically, methods of guideline development, a summary of the supporting evidence, and a justification of the panel’s decisions accompany the recommendations. To use such guidelines optimally, clinicians must understand the implications of the recommendations, assess the trustworthiness of the development process, and evaluate the extent to which the recommendations are applicable to patients in their practice settings. Helpful recommendations are clear and actionable, and explicitly specify whether they are strong or weak, are appropriate for all patients, or depend on individual patients’ circumstances and values. Rigorous guidelines and recommendations are informed by appropriately conducted, up-to-date systematic reviews that consider outcomes important to patients. Because judgments are involved in the interpretation of the evidence and the process of moving from evidence to recommendations, useful guidelines consider all relevant factors that have a bearing in a clinical decision and are not influenced by conflicts of interest.
Conclusions and Relevance
In considering a guideline’s recommendations, clinicians must decide whether there are important differences between the factors the guideline panel has considered in making recommendations and their own practice setting.
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Corresponding Author: Romina Brignardello-Petersen, DDS, MSc, PhD, 1280 Main St W, HSC-2C, Hamilton, ON L8S 4L8, Canada (firstname.lastname@example.org).
Accepted for Publication: August 23, 2021.
Correction: This article was corrected on January 26, 2022, to update a sentence in the Clinical Scenario Resolution section addressing the guideline’s handling of COI.
Author Contributions: Dr Guyatt had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: All authors.
Drafting of the manuscript: Brignardello-Petersen, Carrasco-Labra.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: Brignardello-Petersen, Carrasco-Labra.
Conflict of Interest Disclosures: Dr Guyatt reported being cochair of the GRADE working group. Drs Brignardello-Petersen and Carrasco-Labra are members of the GRADE working group. No other disclosures were reported.
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