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Assessment of Cognitive Function in Patients After COVID-19 Infection

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

People who have survived COVID-19 frequently complain of cognitive dysfunction, which has been described as brain fog. The prevalence of post–COVID-19 cognitive impairment and the association with disease severity are not well characterized. Previous studies on the topic have been limited by small sample sizes and suboptimal measurement of cognitive functioning.1 We investigated rates of cognitive impairment in survivors of COVID-19 who were treated in outpatient, emergency department (ED), or inpatient hospital settings.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: August 17, 2021.

Published: October 22, 2021. doi:10.1001/jamanetworkopen.2021.30645

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Becker JH et al. JAMA Network Open.

Corresponding Author: Jacqueline H. Becker, PhD, Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 (jacqueline.becker@mountsinai.org).

Author Contributions: Drs Becker and Wisnivesky had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Becker, Lin, Wisnivesky.

Acquisition, analysis, or interpretation of data: Becker, Doernberg, Stone, Navis, Festa, Wisnivesky.

Drafting of the manuscript: Becker, Stone, Wisnivesky.

Critical revision of the manuscript for important intellectual content: Becker, Lin, Doernberg, Navis, Festa, Wisnivesky.

Statistical analysis: Becker, Stone, Wisnivesky.

Obtained funding: Wisnivesky.

Administrative, technical, or material support: Becker, Lin, Doernberg, Wisnivesky.

Supervision: Becker, Lin, Doernberg, Navis, Wisnivesky.

Conflict of Interest Disclosures: Dr Wisnivesky reported receiving personal fees from Sanofi, Atea Pharmaceuticals, and Banook Group and grants from Sanofi, Regeneron Pharmaceuticals, and Arnold Consulting outside the submitted work. No other disclosures were reported.

References
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Weintraub  S , Besser  L , Dodge  HH ,  et al.  Version 3 of the Alzheimer Disease Centers’ neuropsychological test battery in the Uniform Data Set (UDS).   Alzheimer Dis Assoc Disord. 2018;32(1):10-17. doi:10.1097/WAD.0000000000000223PubMedGoogle ScholarCrossref
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Benedict  RH , Schretlen  D , Groninger  L , Brandt  J .  Hopkins Verbal Learning Test–Revised: normative data and analysis of inter-form and test-retest reliability.   Clin Neuropsychol. 1998;12(1):43-55. doi:10.1076/clin.12.1.43.1726Google ScholarCrossref
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Helms  J , Kremer  S , Merdji  H ,  et al.  Neurologic features in severe SARS-CoV-2 infection.   N Engl J Med. 2020;382(23):2268-2270. doi:10.1056/NEJMc2008597PubMedGoogle ScholarCrossref
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Pandharipande  PP , Girard  TD , Jackson  JC ,  et al; BRAIN-ICU Study Investigators.  Long-term cognitive impairment after critical illness.   N Engl J Med. 2013;369(14):1306-1316. doi:10.1056/NEJMoa1301372PubMedGoogle ScholarCrossref
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Beraki  S , Aronsson  F , Karlsson  H , Ogren  SO , Kristensson  K .  Influenza A virus infection causes alterations in expression of synaptic regulatory genes combined with changes in cognitive and emotional behaviors in mice.   Mol Psychiatry. 2005;10(3):299-308. doi:10.1038/sj.mp.4001545PubMedGoogle ScholarCrossref
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