Accepted for Publication: September 2, 2021.
Published: November 2, 2021. doi:10.1001/jamanetworkopen.2021.32540
Open Access: This is an open access article distributed under the terms of the CC-BY-NC-ND License. © 2021 Corchado-Garcia J et al. JAMA Network Open.
Corresponding Authors: Tyler Wagner, PhD (firstname.lastname@example.org), and Venky Soundararajan, PhD (email@example.com), nference, One Main St, E Arcade, Cambridge, MA 02142.
Author Contributions: Dr Soundararajan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Corchado-Garcia and Zemmour are co–first authors.
Concept and design: Corchado-Garcia, Zemmour, Lenehan, O’Horo, Badley, Halamka, Virk, Swift, Wagner, Soundararajan.
Acquisition, analysis, or interpretation of data: Corchado-Garcia, Zemmour, Hughes, Bandi, Cristea-Platon, Lenehan, Pawlowski, Bade, O’Horo, Gores, Williams, Badley, Wagner, Soundararajan.
Drafting of the manuscript: Corchado-Garcia, Zemmour, Hughes, Bade, Soundararajan.
Critical revision of the manuscript for important intellectual content: Corchado-Garcia, Zemmour, Hughes, Bandi, Cristea-Platon, Lenehan, Pawlowski, O'Horo, Gores, Williams, Badley, Halamka, Virk, Swift, Wagner, Soundararajan.
Statistical analysis: Corchado-Garcia, Zemmour, Hughes, Bandi, Cristea-Platon, Pawlowski, Bade.
Obtained funding: Badley.
Administrative, technical, or material support: Bade, O’Horo, Badley, Soundararajan.
Supervision: O’Horo, Gores, Badley, Halamka, Wagner, Soundararajan.
Conflict of Interest Disclosures: Dr Corchado-Garcia reported receiving personal fees from and holding stock in nference Inc outside the submitted work. Dr Zemmour reported receiving personal fees from nference Inc outside the submitted work. Dr Hughes reported receiving personal fees from nference Inc during the conduct of the study; and personal fees from nference Inc outside the submitted work. Mr Lenehan reported receiving other fees from Janssen (nference collaborates with Janssen on data science projects unrelated to this manuscript, and this relationship did not impact the study design or interpretation of its results) outside the submitted work. Dr Pawlowski reported receiving personal fees from nference Inc outside the submitted work. Dr O’Horo reported receiving personal fees from Elsevier and Bates College; and grants from nference Inc, outside the submitted work. Dr Badley reported being a consultant for AbbVie and Gilead; serving on scientific advisory boards for Freedom Tunnel, Pinetree Therapeutics, Primmune, Immunome, Flambeau Diagnostics, nference, and Zentalis; serving on data safety and monitoring boards for Corvus, Equillium, and Excision Biotherapeutics; and being founder and president of Splissen Therapeutics. Dr Virk reported being an inventor for Mayo Clinic Travel App interaction with Smart Medical Kit and Medical Kit for Pilgrims. Dr Swift reported receiving grants from Pfizer during the conduct of the study. Dr Wagner reported receiving personal fees from and holding stock in nference Inc outside the submitted work. Dr Soundararajan reported other from Janssen (nference collaborates with Janssen and other biopharmaceutical companies on data science initiatives unrelated to this study, and these collaborations had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript outside the submitted work. The Mayo Clinic may stand to gain financially from the successful outcome of this research. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was in compliance with Mayo Clinic Conflict of Interest policies. No other disclosures were reported.
Additional Information: The data will be made available on reasonable request to the corresponding author. A proposal with detailed description of study objectives and the statistical analysis plan will be needed for evaluation of the reasonability of requests. Deidentified data will be provided after approval from the corresponding author and the Mayo Clinic.
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