Accepted for Publication: September 3, 2021.
Published: November 3, 2021. doi:10.1001/jamanetworkopen.2021.32563
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Conti MG et al. JAMA Network Open.
Corresponding Author: Rita Carsetti, MD, Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale Baldelli 38, 00146 Rome, Italy (rita.carsetti@opbg.net).
Author Contributions: Dr Carsetti had full access to all of the experimental data in the study, and Dr Terrin had full access to all of the clinical data in the study; Drs Carsetti and Terrin take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Conti and Terreri contributed equally to this work and are considered co–first authors. Drs Terrin and Carsetti contributed equally to this work and are considered co–last authors.
Concept and design: Conti, Terreri, Piano Mortari, Zacco, De Luca, Brunelli, Terrin, Carsetti.
Acquisition, analysis, or interpretation of data: Conti, Terreri, Albano, Natale, Boscarino, Zacco, Palomba, Cascioli, Corrente, Capponi, Mirabella, Fernandez Salinas, Marciano, De Luca, Pangallo, Quaranta, Alteri, Russo, Galoppi, Brunelli, Perno, Terrin, Carsetti.
Drafting of the manuscript: Conti, Terreri, Albano, Zacco, Corrente, Capponi, Mirabella, Marciano, De Luca, Pangallo, Quaranta, Russo, Galoppi, Terrin, Carsetti.
Critical revision of the manuscript for important intellectual content: Piano Mortari, Natale, Boscarino, Palomba, Cascioli, Fernandez Salinas, De Luca, Alteri, Russo, Brunelli, Perno, Terrin.
Statistical analysis: Terreri, Boscarino.
Obtained funding: Marciano, Russo, Galoppi, Carsetti.
Administrative, technical, or material support: Conti, Terreri, Piano Mortari, Albano, Natale, Palomba, Cascioli, Corrente, Capponi, Mirabella, Fernandez Salinas, Marciano, Pangallo, Quaranta, Russo, Galoppi, Terrin.
Supervision: Piano Mortari, Russo, Brunelli, Perno, Terrin, Carsetti.
Conflict of Interest Disclosures: None reported.
Funding/Support: Italian Ministry of Health grants RF2013-02358960 and COVID-2020-12371817 and Ricerca Corrente 2021 “5 per mille.”
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
12.Pace
RM , Williams
JE , Järvinen
KM ,
et al. Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19.
mBio. 2021;12(1):e03192-20. doi:
10.1128/mBio.03192-20PubMedGoogle Scholar 16.Miles
DJC , Gadama
L , Gumbi
A , Nyalo
F , Makanani
B , Heyderman
RS . Human immunodeficiency virus (HIV) infection during pregnancy induces CD4 T-cell differentiation and modulates responses to bacille Calmette-Guérin (BCG) vaccine in HIV-uninfected infants.
Immunology. 2010;129(3):446-454. doi:
10.1111/j.1365-2567.2009.03186.xPubMedGoogle ScholarCrossref 17.Mosconi
E , Rekima
A , Seitz-Polski
B ,
et al. Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development.
Mucosal Immunol. 2010;3(5):461-474. doi:
10.1038/mi.2010.23PubMedGoogle ScholarCrossref 23.Diociaiuti
A , Giancristoforo
S , Terreri
S ,
et al. Are SARS-CoV-2 IgA antibodies in paediatric patients with chilblain-like lesions indicative of COVID-19 asymptomatic or paucisymptomatic infection?
J Eur Acad Dermatol Venereol. 2021;35(1):e10-e13. doi:
10.1111/jdv.16934PubMedGoogle ScholarCrossref 25.Conti
MG , Natale
F , Stolfi
I ,
et al. Consequences of early separation of maternal-newborn dyad in neonates born to SARS-CoV-2 positive mothers: an observational study.
Int J Environ Res Public Health. 2021;18(11):5899. doi:
10.3390/ijerph18115899PubMedGoogle ScholarCrossref 27.Carsetti
R , Zaffina
S , Piano Mortari
E ,
et al. Different innate and adaptive immune responses to SARS-CoV-2 infection of asymptomatic, mild, and severe cases.
Front Immunol. 2020;11:610300. doi:
10.3389/fimmu.2020.610300PubMedGoogle Scholar 28.Alteri
C , Cento
V , Antonello
M ,
et al. Detection and quantification of SARS-CoV-2 by droplet digital PCR in real-time PCR negative nasopharyngeal swabs from suspected COVID-19 patients.
PLoS ONE. 2020;15(9):e0236311. doi:
10.1371/journal.pone.0236311PubMed