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SARS-CoV-2 Spike-Specific T-Cell Responses in Patients With B-Cell Depletion Who Received Chimeric Antigen Receptor T-Cell Treatments

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Article Information

Accepted for Publication: September 17, 2021.

Published Online: November 18, 2021. doi:10.1001/jamaoncol.2021.6030

Corresponding Author: Vijay G. Bhoj, MD, PhD, Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, South Tower Pavilion, 8-111, 3400 Civic Ctr Blvd, Philadelphia, PA 19104 (vbhoj@pennmedicine.upenn.edu).

Author Contributions: Drs Parvathaneni and Bhoj had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Dr Parvathaneni and Ms Torres-Rodriguez contributed equally to this work.

Concept and design: Parvathaneni, Frey, Naji, Bhoj.

Acquisition, analysis, or interpretation of data: Parvathaneni, Torres-Rodriguez, Meng, Hwang, Naji, Bhoj.

Drafting of the manuscript: Parvathaneni, Meng, Naji, Bhoj.

Critical revision of the manuscript for important intellectual content: Parvathaneni, Frey, Hwang, Naji, Bhoj.

Statistical analysis: Parvathaneni, Torres-Rodriguez, Meng, Hwang.

Obtained funding: Naji, Bhoj.

Administrative, technical, or material support: Parvathaneni, Meng.

Conflict of Interest Disclosures: Dr Bhoj reported having a patent (US20170051035A1) with royalties paid from Cabaletta Bio. No other disclosures were reported.

Funding/Support: This work was supported by the Gift of Life Transplant Foundation (Drs Naji and Bhoj), the National Blood Foundation (Dr Bhoj), and the Burroughs Wellcome Fund (Dr Bhoj).

Role of the Funder/Sponsor: The Gift of Life Transplant Foundation, the National Blood Foundation, and the Burroughs Wellcome Fund had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: The authors thank the patients for their participation in this study. The authors also thank members of the University of Pennsylvania Oncology COVID Collaborative Group, including Divyansh Agarwal, MD, PhD; Mary Kaminski, PA; Leticia Kuri-Cervantes, PhD; James J. Knox, PhD; Zheng Zhang, MD, PhD; Xiaoming Xu, MS; Jennifer Trofe-Clark, PharmD; Alfred Garfall, MD; Eline T. Luning Prak, MD, PhD; David L. Porter, MD; Carl H. June, MD; and Michael R. Betts, PhD. In addition, the authors Michela Locci, PhD, and Divij Matthew, PhD, for advice related to the T-cell assays; Scott Hensley, PhD, for providing the RBD antigen; Alessandro Sette, PhD, for generously providing the spike protein peptide pools; Diane Mclaughlin and Sarah Benchimol for administrative assistance; Susan Rostami for assistance with sample processing; and David Miklos, MD, PhD; James Gerson, MD; Daniel Landsburg, MD; Saar Gill, MD, PhD; and Stephen Grupp, MD, PhD, for patient referrals. Finally, the authors thank the following cores for assistance: the Human Immunology Core and the Flow Cytometry Core at the University of Pennsylvania, the Clinical Trials Unit and the Clinical Vaccine Production Facility at the University of Pennsylvania, the Clinical and Translational Research Unit at Stanford University, and the Parker Cancer Institute at the University of Pennsylvania.

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