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Growing Public Health Concern of COVID-19 Chronic Olfactory Dysfunction

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Article Information

Accepted for Publication: September 29, 2021.

Published Online: November 18, 2021. doi:10.1001/jamaoto.2021.3379

Corresponding Author: Jay F. Piccirillo, MD, Clinical Outcomes Research Office, Department of Otolaryngology–Head and Neck Surgery, Washington University School of Medicine in St Louis, 660 S Euclid Ave, Campus Box 8115, St Louis, MO 63110 (piccirij@wustl.edu).

Author Contributions: Mr Khan and Dr Kallogjeri had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Khan.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Khan.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: All authors.

Administrative, technical, or material support: Khan.

Supervision: Khan, Piccirillo.

Conflict of Interest Disclosures: Dr Kallogjeri reported stock in Potentia Metrics and personal fees from JAMA Otolaryngology–Head & Neck Surgery outside the submitted work. Dr Piccirillo reported receiving consulting fees from BIND-On-Demand Health Insurance. Research reported in this publication was supported by the National Center For Advancing Translational Sciences of the National Institutes of Health under award number TL1TR002344. No other disclosures were reported.

Disclaimer: Dr Kallogjeri is the Statistics Editor and Dr Piccirillo the Editor of JAMA Otolaryngology–Head & Neck Surgery, but they were not involved in any of the decisions regarding review of the manuscript or its acceptance. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

References
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Tong  JY , Wong  A , Zhu  D , Fastenberg  JH , Tham  T .  The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis.   Otolaryngol Head Neck Surg. 2020;163(1):3-11. doi:10.1177/0194599820926473PubMedGoogle ScholarCrossref
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Lechien  JR , Chiesa-Estomba  CM , Beckers  E ,  et al.  Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients.   J Intern Med. 2021;290(2):451-461. doi:10.1111/joim.13209PubMedGoogle ScholarCrossref
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Hoffman  HJ , Rawal  S , Li  CM , Duffy  VB .  New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction.   Rev Endocr Metab Disord. 2016;17(2):221-240. doi:10.1007/s11154-016-9364-1PubMedGoogle ScholarCrossref
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