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Risks of SARS-CoV-2 Breakthrough Infection and Hospitalization in Fully Vaccinated Patients With Multiple Myeloma

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Article Information

Accepted for Publication: October 11, 2021.

Published: November 23, 2021. doi:10.1001/jamanetworkopen.2021.37575

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Wang L et al. JAMA Network Open.

Corresponding Authors: Nathan A. Berger, MD, Center for Science, Health, and Society, 2103 Cornell Rd, Cleveland, OH 44106 (nab@case.edu); Rong Xu, PhD, Center for Artificial Intelligence in Drug Discovery, 2103 Cornell Rd, Cleveland, OH 44106 (rxx@case.edu).

Author Contributions: Dr Xu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Wang, Xu.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Wang, Xu.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Wang.

Obtained funding: Berger, Xu.

Administrative, technical, or material support: Xu.

Supervision: Berger, Xu.

Conflict of Interest Disclosures: Dr Berger reported grants from the National Institutes of Health (NIH) during the conduct of the study. No other disclosures were reported.

Funding/Support: We acknowledge support from NIH National Cancer Institute R25CA221718, American Cancer Society Research Scholar Grant RSG-16-049-01 – MPC, NIH National Institute of Aging R01 AG057557, R01 AG061388, R56 AG062272, National Institute on Alcohol Abuse and Alcoholism (grant No. R01AA029831), The Clinical and Translational Science Collaborative (CTSC) of Cleveland 1UL1TR002548-01, Case Comprehensive Cancer Center P30 CA043703, Case Comprehensive Cancer Center Cancer Health Disparities SPORE Planning Grant P20 CA2332216.

Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: We would like to thank David C Kaelber, MD, PhD, MPH, from The MetroHealth System and Case Western Reserve University for facilitating our access to TriNetX.

References
1.
Wang  Q , Berger  NA , Xu  R .  When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities.   Blood Rev. 2021;47:100775. doi:10.1016/j.blre.2020.100775PubMedGoogle Scholar
2.
Wang  Q , Berger  NA , Xu  R .  Analyses of risk, racial disparity, and outcomes among US patients with cancer and COVID-19 infection.   JAMA Oncol. 2021;7(2):220-227. doi:10.1001/jamaoncol.2020.6178PubMedGoogle ScholarCrossref
3.
Van Oekelen  O , Gleason  CR , Agte  S ,  et al; PVI/Seronet team.  Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma.   Cancer Cell. 2021;39(8):1028-1030. doi:10.1016/j.ccell.2021.06.014PubMedGoogle ScholarCrossref
4.
Re  D , Barrière  J , Chamorey  E ,  et al.  Low rate of seroconversion after mRNA anti-SARS-CoV-2 vaccination in patients with hematological malignancies.   Leuk Lymphoma. 2021;1-3. doi:10.1080/10428194.2021.1957877PubMedGoogle Scholar
5.
TriNetX Analytics Network. Accessed October 8, 2021. https://trinetx.com/
6.
von Elm  E , Altman  DG , Egger  M , Pocock  SJ , Gøtzsche  PC , Vandenbroucke  JP ; STROBE Initiative.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.   Bull World Health Organ. 2007;85(11):867-872. doi:10.2471/BLT.07.045120PubMedGoogle ScholarCrossref
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