Corresponding Author: Kim L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, The University of Melbourne, 161 Barry St, Carlton, VIC 3010, Australia (k.bennell@unimelb.edu.au).
Accepted for Publication: October 12, 2021.
Author Contributions: Drs Bennell and Kasza had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Bennell and Paterson are co–first authors and contributed equally to the article.
Concept and design: Bennell, Paterson, Kasza, Y. Wang, Cicuttini, Buchbinder, Harris, Connell, Linklater, Hunter.
Acquisition, analysis, or interpretation of data: Bennell, Metcalf, Duong, Eyles, Kasza, Y. Wang, Cicuttini, Buchbinder, Forbes, Yu, Connell, Linklater, B. Wang, Oo, Hunter.
Drafting of the manuscript: Bennell, Paterson, Metcalf, Kasza, Linklater.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Metcalf, Kasza, Forbes.
Obtained funding: Bennell, Y. Wang, Buchbinder, Hunter.
Administrative, technical, or material support: Paterson, Metcalf, Duong, Eyles, Cicuttini, Harris, Yu, Linklater, B. Wang.
Supervision: Bennell, Paterson, Eyles, Y. Wang, Cicuttini, Connell, Linklater, Hunter.
Conflict of Interest Disclosures: Dr Bennell reported receiving personal fees from Wolters Kluwer for production of UpToDate knee OA clinical guidelines. Dr Paterson reported receiving grants from the Australian National Health and Medical Research Council (NHMRC) outside the submitted work. Dr Buchbinder report receiving funding from the NHMRC outside the submitted work. Dr Yu reported receiving royalties from Wolters Kluwer for contributions to UpToDate. Mr Connell reported providing PRP injections in clinical practice (Imaging @ Olympic Park). Dr Linklater reported providing PRP injections in clinical practice (Castlereagh Imaging). Dr Hunter reported receiving personal fees for scientific advisory board membership from Biobone, Novartis, Tissuegene, Pfizer, and Lilly. No other disclosures were reported.
Funding/Support: The study was funded by NHMRC project grant 1106274. Regen Lab SA provided the commercial kits free of charge.
Role of the Funder/Sponsor: The NHMRC, the University of Melbourne, and Regen Lab SA had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Data Sharing Statement: See Supplement 4.
Additional Contributions: We thank Paris Arlegui (Imaging @ Olympic Park), for administrative assistance; Jade McTernan, BSc, Naomi Haverty, BSN, and Tom Entwisle, MBBS (all from Imaging @ Olympic Park), and Annie Phillips, DipAppSci, Jennie Noakes, BMed, and Danielle Pryke, GDip (all from Castlereagh Imaging), for assisting with administration of PRP injections; and Sarah Robbins, BPhty (University of Sydney), for assisting with project management. Their roles were supported through the NHMRC research grant.