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Serologic Testing for Hepatitis B

Educational Objective
To understand how to interpret the results of diagnostic tests and apply them clinically.
1 Credit CME

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Article Information

Corresponding Author: Maroun M. Sfeir, MD, MPH, MS, Department of Pathology and Laboratory Medicine, Clinical Microbiology Laboratories, University of Connecticut Health Center, Farmington, CT 06053 (sfeir@uchc.edu).

Published Online: November 19, 2021. doi:10.1001/jama.2021.19803

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
1.
Hepatitis B. Centers for Disease Control and Prevention. Accessed August 7, 2020. https://www.cdc.gov/hepatitis/hbv/index.htm
2.
Terrault  NA , Lok  ASF , McMahon  BJ ,  et al.  Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.   Hepatology. 2018;67(4):1560-1599. doi:10.1002/hep.29800PubMedGoogle ScholarCrossref
3.
Raimondo  G , Locarnini  S , Pollicino  T , Levrero  M , Zoulim  F , Lok  AS ; Taormina Workshop on Occult HBV Infection Faculty Members.  Update of the statements on biology and clinical impact of occult hepatitis B virus infection.   J Hepatol. 2019;71(2):397-408. doi:10.1016/j.jhep.2019.03.034PubMedGoogle ScholarCrossref
4.
Makvandi  M .  Update on occult hepatitis B virus infection.   World J Gastroenterol. 2016;22(39):8720-8734. doi:10.3748/wjg.v22.i39.8720PubMedGoogle ScholarCrossref
5.
Yuen  MF , Lee  CK , Wong  DK ,  et al.  Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population.   Gut. 2010;59(10):1389-1393. doi:10.1136/gut.2010.209148PubMedGoogle ScholarCrossref
6.
Clinical laboratory fee schedule. Updated October 1, 2021. Accessed November 15, 2021. https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/ClinicalLabFeeSched/index
7.
Patel  EU , Thio  CL , Boon  D , Thomas  DL , Tobian  AAR .  Prevalence of hepatitis B and hepatitis D virus infections in the United States, 2011-2016.   Clin Infect Dis. 2019;69(4):709-712. doi:10.1093/cid/ciz001PubMedGoogle ScholarCrossref
8.
Amini  A , Varsaneux  O , Kelly  H ,  et al.  Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis.   BMC Infect Dis. 2017;17(suppl 1):698. doi:10.1186/s12879-017-2772-3PubMedGoogle ScholarCrossref
9.
Chou  R , Blazina  I , Bougatsos  C ,  et al.  Screening for hepatitis B virus infection in nonpregnant adolescents and adults: a systematic review for the US Preventive Services Task Force.   JAMA. 2020;324(23):2423-2436. PubMedGoogle ScholarCrossref
10.
Guidelines on Hepatitis B and C Testing. World Health Organization; 2017. http://apps.who.int/iris/bitstream/handle/10665/254621/9789241549981-eng.pdf
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