Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine | Acute Coronary Syndromes | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

The BNT162b2 mRNA vaccine (Pfizer-BioNTech) was the first SARS-CoV-2 vaccine authorized and the most widely used in older persons in France. Although no increases in cardiovascular events were reported in phase 3 trials,1 questions emerged once the vaccine was used on a large scale because older people were underrepresented in the trials. We evaluated the short-term risk of severe cardiovascular events among French people aged 75 years or older after the administration of the BNT162b2 mRNA vaccine.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Marie Joelle Jabagi, PharmD, PhD, EPI-PHARE, 143-147 Boulevard Anatole France, F-93285 Saint-Denis CEDEX, France (marie-joelle.jabagi@ansm.sante.fr).

Accepted for Publication: November 15, 2021.

Published Online: November 22, 2021. doi:10.1001/jama.2021.21699

Author Contributions: Dr Jabagi and Ms Bertrand had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Jabagi, Botton, Bertrand, Weill, Zureik, Dray-Spira.

Drafting of the manuscript: Jabagi, Bertrand, Zureik.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Jabagi, Botton, Bertrand, Farrington.

Supervision: Botton, Weill, Zureik, Dray-Spira.

Conflict of Interest Disclosures: None reported.

Additional Contributions: Stephane Le Vu, PharmD, PhD, and Kim Bouillon, MD, PhD, EPI-PHARE, reviewed the manuscript without compensation. Bérangère Baricault, MSc, and Jerome Drouin, MSc, EPI-PHARE, provided unpaid technical support related to data management.

References
1.
Polack  FP , Thomas  SJ , Kitchin  N ,  et al; C4591001 Clinical Trial Group.  Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine.   N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577PubMedGoogle ScholarCrossref
2.
Farrington  CP , Whitaker  HJ , Hocine  MN .  Case series analysis for censored, perturbed, or curtailed post-event exposures.   Biostatistics. 2009;10(1):3-16. doi:10.1093/biostatistics/kxn013PubMedGoogle ScholarCrossref
3.
Barda  N , Dagan  N , Ben-Shlomo  Y ,  et al.  Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting.   N Engl J Med. 2021;385(12):1078-1090. doi:10.1056/NEJMoa2110475PubMedGoogle ScholarCrossref
4.
Klein  NP , Lewis  N , Goddard  K ,  et al.  Surveillance for adverse events after COVID-19 mRNA vaccination.   JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close