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Would a multimodal strategy of mitigation and testing be adequate to safely reopen a residential historically Black college and university (HBCU) campus in the setting of increasing COVID-19 positivity rates?
In this cohort study among 2320 individuals at a publicly funded HBCU, combining an active messaging campaign on shared responsibility and mitigation measures with frequent polymerase chain reaction testing was associated with decreased COVID-19 positivity rates compared with the surrounding community. The need for isolation and quarantine dormitory occupancy was limited.
This study found that, in the setting of increased community COVID-19 positivity rates and the absence of a vaccine, well-described mitigation efforts and frequent testing were associated with decreased spread of disease.
COVID-19 posed an unprecedented threat to residential colleges in the fall of 2020. While there were mathematical models of COVID-19 transmission, there were no established or tested protocols of COVID-19 testing or mitigation for school administrators to follow.
To investigate the association of a multifaceted COVID-19 mitigation strategy using social, behavioral, and educational interventions and a program of frequent testing with prevalence of disease spread.
Design, Setting, and Participants
This cohort study was conducted as a retrospective review of COVID-19 positivity from August 16, 2020, to April 30, 2021, at Delaware State University, a publicly funded historically Black university. Participants included all students, faculty, and staff members with a campus presence. Positivity rates after use of mitigation strategies and testing on campus were compared with those of the surrounding community. Data were analyzed from July through September 2021.
Mitigation strategies included education and outreach about social distancing, masking, and handwashing, and a COVID-19 testing plan consisted of twice-weekly polymerase chain reaction (PCR) screening using anterior nasal samples (fall and early spring semester) and then saliva-based samples (middle to late spring semester).
Main Outcomes and Measures
Cumulative tests, infections, daily quarantine, and isolation residence hall occupancy were measured, and comparisons were made with statewide COVID-19 positivity rates.
The campus cohort included 2320 individuals (1575 resident students, 415 nonresident students, and 330 faculty or staff members). There were 1488 (64.1%) women and 832 (35.9%) men; mean (SD) age was 27.5 (12.9) years. During the fall semester, 36 500 COVID-19 PCR tests were performed. Weekly positivity rates ranged from 0 of 372 tests to 16 of 869 tests (1.8%) (mean [SD] positivity rate, 0.5% [0.5%]; 168 positive results and 36 312 negative results). During the same period, statewide positivity ranged from 589 of 25 120 tests (2.3%) to 5405 of 54 596 tests (9.9%) (mean [SD] positivity rate, 4.8% [2.6%]). In the spring semester, 39 045 PCR tests were performed. Weekly positivity rates ranged from 4 of 2028 tests (0.2%) to 36 of 900 tests (4.0%) (mean [SD] positivity rate, 0.8% [0.9%]; 267 positive results and 38 767 negative results). During the same period, statewide positivity ranged from 1336 of 37 254 tests (3.6%) to 3630 of 42 458 tests (8.5%) (mean [SD] positivity rate, 5.1% [1.3%]). Compared with statewide rates, campus positivity rates were mean (SD) 4.4 (2.6) percentage points lower during the fall semester (P < .001) and mean (SD) 5.6 (1.6) percentage points lower during the spring semester (P < .001). Total daily quarantine and isolation residence hall occupancy ranged from 0 to 43 students in the fall and 1 to 47 students during the spring.
Conclusions and Relevance
This study found that the combination of campuswide mitigation policies and twice-weekly COVID-19 PCR screening was associated with a significant decrease in COVID-19 positivity at a residential historically Black university campus compared with the surrounding community. Given the socioeconomic demographics of many students at historically Black colleges and universities, keeping these resident campuses open is critical not only to ensure access to educational resources, but also to provide housing and food security.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: October 5, 2021.
Published: December 13, 2021. doi:10.1001/jamanetworkopen.2021.37189
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Hockstein NG et al. JAMA Network Open.
Corresponding Author: Neil G. Hockstein, MD, ENT and Allergy of Delaware, 700 Prides Crossing, Ste 200, Newark, DE 19713 (firstname.lastname@example.org).
Author Contributions: Dr. Hockstein had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Hockstein, Moultrie, Mason, Scott, Coker, Tuxward, DeLauder, Allen.
Acquisition, analysis, or interpretation of data: Hockstein, Fisher, Scott, Terheyden, Canter, Coons.
Drafting of the manuscript: Hockstein, Moultrie, Canter, Coons, Allen.
Critical revision of the manuscript for important intellectual content: Fisher, Mason, Scott, Coker, Tuxward, Terheyden, DeLauder.
Statistical analysis: Hockstein, Scott, Canter, Coons.
Obtained funding: Hockstein, Allen.
Administrative, technical, or material support: Hockstein, Moultrie, Fisher, Mason, Scott, Tuxward, Terheyden, DeLauder, Allen.
Conflict of Interest Disclosures: Ms Moultrie and Drs Fisher and Mason reported receiving grants from Testing for America (TFA) during the conduct of the study. Dr Mason reported receiving grants from Testing for America outside the submitted work. Lt Tuxward reported receiving consulting fees from TFA during the conduct of the study. Ms Terheyden reported receiving personal fees from TFA during the conduct of the study. No other disclosures were reported.
Funding/Support: This project was supported by the Testing for America Board of Directors.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
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