A patient with a history of normal-tension glaucoma presented with a blurred spot in the central vision of the right eye. Examination showed best-corrected visual acuity of 20/50 OD, 20/30 OS, and intraocular pressure of 13 mm Hg OU. In the right eye, dilated fundus examination and optical coherence tomography (OCT) of the macula revealed subretinal fluid and cystoid spaces within the outer nuclear layer and inner nuclear layer in the nasal macula (Figure 1). Results of the left eye fundus examination and macular OCT were normal. In both eyes, the optic cup appeared very deep with a large cup-disc ratio.
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C. OCT of the optic nerve head
The differential diagnosis of macular fluid includes choroidal neovascularization, central serous chorioretinopathy, myopic foveoschisis, optic pit maculopathy, and cystoid macular edema. In this case, the subretinal and intraretinal fluid in multiple retinal layers contiguous with the optic nerve point to the optic nerve, rather than vascular leakage, as the source of the fluid. Therefore, fluorescein angiography (choice B) and OCT-angiography of the macula (choice D), tests that detect vascular sources of fluid, are not indicated, and anti–vascular endothelial growth factor (choice A), a treatment for vascular leakage, is not appropriate.
Although optic pit maculopathy without inner retinal schisis cavity has been reported, the pattern and distribution of fluid is most consistent with optic pit maculopathy.1,2 However, clinical examination and OCT of the optic nerve revealed a very deep cup (1388 μm from the Bruch membrane opening) without a focal depression seen in optic pit (Figure 2).
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Eileen S. Hwang, MD, PhD, Department of Ophthalmology and Visual Sciences, University of Utah, 65 Mario Capecchi Dr, Salt Lake City, UT 84132 (email@example.com).
Published Online: January 6, 2022. doi:10.1001/jamaophthalmol.2021.3326
Conflict of Interest Disclosures: Dr Hwang reports nonfinancial support from Regeneron, Beaver Vistec, Katalys, Alcon, and Bausch & Lomb. Dr Kim reports personal fees from Allergan, Adverum, Astellas, Genentech, Novartis, and Regeneron and research support from Heidelberg, Notal Vision, and Optos. No other disclosures were reported.
Meeting Presentation: This work was presented by Dr Kim at the Hawaiian Eye/Retina Meeting; January 13, 2018; Kihei, Hawaii.
Additional Contributions: We thank Marriner Altmann, CRA, OCT-C, CPT, Medical College of Wisconsin/Froedtert Eye Institute, for obtaining the images. She did not receive compensation.
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