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On November 24, 2021, a SARS-CoV-2 variant of concern, Omicron (B.1.1.529), was identified in South Africa as responsible for a fourth wave of COVID-19.1,2 The high number of spike mutations has raised concerns about its ability to evade vaccine and spread.3,4 We assessed hospitalized patients with a positive SARS-CoV-2 test result during the fourth wave compared with previous waves.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Caroline Maslo, MD, PhD, Netcare, 76 Maude St, Sandton 2196, Johannesburg, South Africa (email@example.com).
Accepted for Publication: December 27, 2021.
Published Online: December 30, 2021. doi:10.1001/jama.2021.24868
Author Contributions: Dr Maslo and Ms Kama had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Maslo, Friedland.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Maslo, Friedland.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Maslo, Akaloo.
Administrative, technical, or material support: Laubscher, Toubkin, Kama.
Supervision: Maslo, Friedland, Laubscher.
Conflict of Interest Disclosures: None reported.
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