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A Perplexing Pediatric Parotid Mass

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
1 Credit CME

A previously healthy 8-year-old boy presented to an outpatient clinic for further evaluation of a fluctuating right parotid mass that had been present for 3 years. The patient was not immunocompromised and denied any trauma to the area. In the 2 months prior, he had received multiple rounds of antibiotics from other health care professionals. Outside computed tomography of the face showed a 3-cm cystic structure in the superficial aspect of the right parotid gland with associated lymphadenopathy. An outside health care professional had attempted incision and drainage of the area with negative cultures. The patient presented to our clinic with an isolated right 2-cm fluctuant and tender mass overlying the parotid gland. There was no accompanying cervical lymphadenopathy, and facial nerve function remained fully intact. The patient denied fevers or systemic symptoms. Results of laboratory evaluation revealed normal complete blood cell count and erythrocyte sedimentation rate levels with negative infectious workup results for Epstein-Barr virus, cytomegalovirus, HIV, and tuberculosis (TB). Magnetic resonance imaging showed a 1.9-cm peripherally enhancing, centrally necrotic lesion overlying the superficial right parotid gland with multiple subcentimeter necrotic lymph nodes within the right parotid gland (Figure 1).

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A previously healthy 8-year-old boy presented to an outpatient clinic for further evaluation of a fluctuating right parotid mass that had been present for 3 years. The patient was not immunocompromised and denied any trauma to the area. In the 2 months prior, he had received multiple rounds of antibiotics from other health care professionals. Outside computed tomography of the face showed a 3-cm cystic structure in the superficial aspect of the right parotid gland with associated lymphadenopathy. An outside health care professional had attempted incision and drainage of the area with negative cultures. The patient presented to our clinic with an isolated right 2-cm fluctuant and tender mass overlying the parotid gland. There was no accompanying cervical lymphadenopathy, and facial nerve function remained fully intact. The patient denied fevers or systemic symptoms. Results of laboratory evaluation revealed normal complete blood cell count and erythrocyte sedimentation rate levels with negative infectious workup results for Epstein-Barr virus, cytomegalovirus, HIV, and tuberculosis (TB). Magnetic resonance imaging showed a 1.9-cm peripherally enhancing, centrally necrotic lesion overlying the superficial right parotid gland with multiple subcentimeter necrotic lymph nodes within the right parotid gland (Figure 1).

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Article Information

Corresponding Author: Phayvanh P. Pecha, MD, Department of Otolaryngology–Head & Neck Surgery, College of Medicine, Medical University of South Carolina, Rutledge Tower, 135 Rutledge Ave, MSC 550, Ste 1130, Charleston, SC 29425 (pechap@musc.edu).

Published Online: January 6, 2022. doi:10.1001/jamaoto.2021.3879

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient’s mother for granting permission to publish this information.

References
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Winburn  B , Sharman  T .  Atypical Mycobacterial Disease. StatPearls Publishing; 2021.
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Blyth  CC , Best  EJ , Jones  CA ,  et al.  Nontuberculous mycobacterial infection in children: a prospective national study.   Pediatr Infect Dis J. 2009;28(9):801-805. doi:10.1097/INF.0b013e31819f7b3f PubMedGoogle ScholarCrossref
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Reuss  AM , Wiese-Posselt  M , Weissmann  B ,  et al.  Incidence rate of nontuberculous mycobacterial disease in immunocompetent children: a prospective nationwide surveillance study in Germany.   Pediatr Infect Dis J. 2009;28(7):642-644. doi:10.1097/INF.0b013e3181978e8e PubMedGoogle ScholarCrossref
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Haverkamp  MH , Arend  SM , Lindeboom  JA , Hartwig  NG , van Dissel  JT .  Nontuberculous mycobacterial infection in children: a 2-year prospective surveillance study in the Netherlands.   Clin Infect Dis. 2004;39(4):450-456. doi:10.1086/422319 PubMedGoogle ScholarCrossref
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Griffith  DE , Aksamit  T , Brown-Elliott  BA ,  et al; ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America.  An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.   Am J Respir Crit Care Med. 2007;175(4):367-416. doi:10.1164/rccm.200604-571ST PubMedGoogle ScholarCrossref
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Bhattacharya  J , Mohandas  S , Goldman  DL .  Nontuberculous mycobacterial infections in children.   Pediatr Rev. 2019;40(4):179-190. doi:10.1542/pir.2018-0131 PubMedGoogle ScholarCrossref
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Zimmermann  P , Tebruegge  M , Curtis  N , Ritz  N .  The management of non-tuberculous cervicofacial lymphadenitis in children: a systematic review and meta-analysis.   J Infect. 2015;71(1):9-18. doi:10.1016/j.jinf.2015.02.010 PubMedGoogle ScholarCrossref
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Wei  JL , Bond  J , Sykes  KJ , Selvarangan  R , Jackson  MA .  Treatment outcomes for nontuberculous mycobacterial cervicofacial lymphadenitis in children based on the type of surgical intervention.   Otolaryngol Head Neck Surg. 2008;138(5):566-571. doi:10.1016/j.otohns.2008.01.022PubMedGoogle ScholarCrossref
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Rist  TM , Baglam  T , Pecha  PP . Parotid non-tuberculosis mycobacterium infection and systematic review of the literature. Poster presented at: Combined Otolaryngology Spring Meetings 2021; April 27-May 1, 2021.
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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