Accepted for Publication: December 6, 2021.
Published: January 12, 2022. doi:10.1001/jamanetworkopen.2021.46168
Correction: This article was corrected on February 14, 2021, to fix errors in the presentation of data in the Abstract, main text, and Supplement 1.
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Beauchamp MK et al. JAMA Network Open.
Corresponding Author: Parminder Raina, PhD, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, 309A McMaster Innovation Park (MIP), 1280 Main St. W. Hamilton, ON L8S 4K1, Canada (praina@mcmaster.ca).
Author Contributions: Dr Raina had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Beauchamp and Joshi contributed equally as co–first authors.
Concept and design: Beauchamp, McMillan, Basta, Kirkland, Raina.
Acquisition, analysis, or interpretation of data: Beauchamp, Joshi, Erbas Oz, Griffith, Kirkland, Wolfson, Raina.
Drafting of the manuscript: Beauchamp, Joshi, McMillan, Raina.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Beauchamp, Erbas Oz, Raina.
Obtained funding: Kirkland, Wolfson, Raina.
Administrative, technical, or material support: Basta, Kirkland, Raina.
Supervision: Raina.
Conflict of Interest Disclosures: None reported.
Funding/Support: Funding for the support of the CLSA COVID-19 Questionnaire-based study was provided by Juravinski Research Institute, Faculty of Health Sciences, McMaster University, Provost Fund from McMaster University, McMaster Institute for Research on Aging, Public Health Agency of Canada and Government of Nova Scotia. Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant No. LSA 94473 and the Canada Foundation for Innovation.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
The Canadian Longitudinal Study on Aging Team: The Members of the Canadian Longitudinal Study on Aging Team are listed in Supplement 2.
Disclaimer: The opinions expressed in this manuscript are the authors’ own and do not reflect the views of the Canadian Longitudinal Study on Aging.
Additional Contributions: This research was conducted using the CLSA Baseline Tracking Dataset version 3.7, Baseline Comprehensive Dataset version 5.1, Follow-up 1 Tracking Dataset version 2.2, Follow-up 1 Comprehensive Dataset version 3.0, CLSA Sample Weights Version 1.2, and COVID-19 questionnaire data under Application ID No. 21CON001. The CLSA is led by Drs. Raina, Wolfson, and Kirkland. Dr Raina holds the Raymond and Margaret Labarge Chair in Optimal Aging and Knowledge Application for Optimal Aging, is the Director of the McMaster Institute for Research on Aging and the Labarge Centre for Mobility in Aging, and holds a Tier 1 Canada Research Chair in Geroscience. Dr Beauchamp holds a Tier 2 Canada Research Chair in Mobility, Aging, and Chronic Disease. Lauren Griffith is supported by the McLaughlin Foundation Professorship in Population and Public Health.
4.Taquet
M , Geddes
JR , Husain
M , Luciano
S , Harrison
PJ . 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records.
Lancet Psychiatry. 2021;8(5):416-427. doi:
10.1016/S2215-0366(21)00084-5PubMedGoogle ScholarCrossref 6.Belli
S , Balbi
B , Prince
I ,
et al. Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation.
Eur Respir J. 2020;56(4):2002096. doi:
10.1183/13993003.02096-2020PubMedGoogle Scholar 9.Halpin
SJ , McIvor
C , Whyatt
G ,
et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation.
J Med Virol. 2021;93(2):1013-1022. doi:
10.1002/jmv.26368PubMedGoogle ScholarCrossref 17.World Health Organization. Global Recommendations on Physical Activity for Health. World Health Organization; 2010.
21.Vanichkachorn
G , Newcomb
R , Cowl
CT ,
et al. Post-COVID-19 syndrome (long haul syndrome): description of a multidisciplinary clinic at Mayo Clinic and characteristics of the initial patient cohort.
Mayo Clin Proc. 2021;96(7):1782-1791. doi:
10.1016/j.mayocp.2021.04.024PubMedGoogle ScholarCrossref 25.Desforges
M , Le Coupanec
A , Dubeau
P ,
et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system?
Viruses. 2019;12(1):E14. doi:
10.3390/v12010014PubMedGoogle Scholar 28.Poenaru
S , Abdallah
SJ , Corrales-Medina
V , Cowan
J . COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.
Ther Adv Infect Dis. 2021;8:20499361211009385. doi:
10.1177/20499361211009385PubMedGoogle Scholar 31.Perracini
MR , de Amorim
JSC , Lima
CA ,
et al; REMOBILIZE Research Network (CANSORT-SCI). Impact of COVID-19 pandemic on life-space mobility of older adults living in Brazil: REMOBILIZE study.
Front Public Health. 2021;9:643640. doi:
10.3389/fpubh.2021.643640PubMedGoogle Scholar 32.Sepúlveda-Loyola
W , Rodríguez-Sánchez
I , Pérez-Rodríguez
P ,
et al. Impact of social isolation due to COVID-19 on health in older people: mental and physical effects and recommendations.
J Nutr Health Aging. 2020;24(9):938-947. doi:
10.1007/s12603-020-1500-7PubMedGoogle ScholarCrossref