Original Investigation
Combination Casirivimab and Imdevimab and Development of Symptomatic COVID-19 in SARS-CoV-2 Infection
Meagan P. O’Brien, MD; Eduardo Forleo-Neto, MD; Neena Sarkar, PhD; Flonza Isa, MD; Peijie Hou, PhD; Kuo-Chen Chan, PhD; Bret J. Musser, PhD; Katharine J. Bar, MD; Ruanne V. Barnabas, MD; Dan H. Barouch, MD, PhD; Myron S. Cohen, MD; Christopher B. Hurt, MD; Dale R. Burwen, MD, MPH; Mary A. Marovich, MD; Elizabeth R. Brown, ScD; Ingeborg Heirman, PhD; John D. Davis, PhD; Kenneth C. Turner, PhD; Divya Ramesh, PhD; Adnan Mahmood, MD; Andrea T. Hooper, PhD; Jennifer D. Hamilton, PhD; Yunji Kim, PharmD; Lisa A. Purcell, PhD; Alina Baum, PhD; Christos A. Kyratsous, PhD; James Krainson, MD, CPI, RPSGT; Richard Perez-Perez, MD; Rizwana Mohseni, DO; Bari Kowal, MS; A. Thomas DiCioccio, PhD; Gregory P. Geba, MD, DrPH; Neil Stahl, PhD; Leah Lipsich, PhD; Ned Braunstein, MD; Gary Herman, MD; George D. Yancopoulos, MD, PhD; David M. Weinreich, MD; COVID-19 Phase 3 Prevention Trial Team; Neal Warshoff; Liudmila Moreiras; Dario Altamirano; Dickson Ellington; Faisal Faikih; William Smith; Richard Gibson; Katie Buckner; Robert Rosen; Amy Sapp; Anita Kohli; Vicki McIntyre; Yessica Sachdeva; Amanda McFarland; Dina Gibson; Kenneth Kim; Jason Ahn; Lisa Neinchel; Nayna Paryani; Amber Mottola; Eva Day; Martha Navarro; Rafaelito Victoria; Xanthe Victoria; Rene Uong; Mindy Sampson; Christopher Polk; Michael Leonard; Lewis McCurdy; Leigh A. Medaris; Zainab Shahid; Lisa Davidson; Jawad Nazir; John Lee; Amy Elliott; Swami Sathyanaryan; Mansi Oberoi; Muhammad (Danial) Siddiqui; Muhammad Arsad; Kara Bruning; Sybil Hosek; Temitope Oyedele; Vanessa Sarda; Monica Mercon; Kathryn Stephenson ; Boris Juelg; Chen Sabrina Tan; Rebecca Zash; Ai-ris Collier; Jessica Ansel; Kate Jaegle; Lilia Roque-Guerrero; Ana Gomez Ramirez; Javier Capote; Gisel Paz; Michael Paasche-Orlow; Julien Dedier; Sanjay Vadgama; Ramachandra Patak; Nicolas Chronos; Cary Hefty; Judith Borger; Ifeanyi Momodu; Lindsey Carswell; Benjamin King; Ryan Starr; Scott Syndergaard; Nancy Patel; Ravikumar Patel; Ryan Sattar; Jeffrey Unger; Sheila De Jesus-Maranan; Cecilia Casaclang; Michael Seep; Celeste Brown; Joshua Whatley; Dennis Levinson; Saad Alvi; Norman James; Azazuddin Ahmed; Robinson Koilpillai; Stephanie Cassady; Jennifer Cox; Eduardo Torres; Mark J. Rosenthal; Michael Winnie; Jerry Plemons; Omesh Verma; Richard Leggett; Ramon Reyes; Keith Beck; Brian Poliquin; Murtaza Mussaji; Jignesh Shah; David Sutton; Edward Pereira; Rodel Gloria; Stacey Kelly; Amy Dennis-Saltz; Mae Sheikh-Ali; Elias Saikali; James Magee; Rebecca Goldfaden; Haresh Boghara; Sunny Patel; Bari Eichelbaum; Duane Anderson; Sean Su; Alexander Akhavan; Diana Kirby; Joy Venglik; Kenneth Mayer; Taimur Khan; Marcy Gelman; Faisal A. Fakih; Faisal M. Fakih; Daniel Layish; Fernando Alvarado; Jose Diaz; Augusto Focil; Griselda Rosas; Stevan Correa; Michael Bogseth; Bhaktasharan Patel; Gary Tarshis; Katrina Grablin; Paul Simonelli ; Stanley Martin; Alvin Sharma; Anna Chen; Pragya Dhaubhadel; Shaeesta Khan; Sreelatha Naik; Sudheer Penupolu; Thulashie Sivarajah; Tae-Sung Kwon; Lakshmi Saladi; Farbod Raiszadeh; Sharon Mannheimer; Raji Ayinla; Khaing Myint; Akari Kyaw; Donna Dowie; Robin O'Reilly; Hussein Assallum; Lovelyamma Varghese; Ellen Morrison; Julie Franks; Jun Avelino Loquere; Orlando Rosario; Andrea Low; Joan Villacrucis; Alan Skolnick; Harold Minkowitz; David Leiman; Todd Price; Anatoli Krasko; Idisoro Wiener; Larry Reed; Oscar Lin; Mayur Ramesh; George Alangaden; Suraj Saggar; Thomas Birch; Benjamin De La Rosa; Karyna Neyra; Erina Kunwar; Jeffrey Kingsley; April Pixler; Veronica McBride; Judith Aberg; Michelle Cespedes; Alexandra Abrams-Downey; Erna Kojic; Luz Lugo; Sean Liu; Nadim Salomon; David Perlman; Deena Altman; Farah Rahman; Georgina Osorio; Joseph Mathew; Sanjana Koshy; Dana Mazo; Francesca Cossarini; Sondra Middleton; Alina Jen; Erika Maria Reategui Schwarz; Miguel Trevino; Benjamin DeVries; Vidya Menon; Moiz Kasubhai; Usha Venugopal; Anjana Pillai; Franscene Oulds; Matthew Hong; Wayne Harper; Lynn Eckert; Douglas Wadeson; Lisa Cohen; Joel Chua; Shyam Kottilil; Jennifer Husson; John Baddley; R. Gentry Wilkerson; Shivakumar Narayanan; Uzoamaka Eke; Myint Noe; Melanie Malave Sanchez; Arthur Kim; Greg Robbins; Mark Siedner; Rajesh Gandhi; Kristen Hysell; Jacob Lazarus; Lael Yonker; Roberto Arduino; Karen J. Vigil; Carlos J. Bello; Esperanza Arce-Nunez; Jorge Acosta; Julio L. Arronte; Eric Meissner; Patrick Flume; Andrew Goodwin; Deeksha Jandhyala; Nandita Nadig; Robert Jeanfreau; Susan Jeanfreau; Susan Tortorich; Shiva Akula; Paul Matherne; Donald Gaddy; Magdy Mikhail; Rajasekaran Annamalai; Huy Nguyen; Nizar Nayani; Mahalakshmi Ramchandra; Priyesh Mehta; Jacqueline Horne; Grace Hassan; Godson Oguchi; Judepatricks Onyema; Moti Ramgopal; Brenda Jacobs; Lisa Cason; Angela Trodglen; Adrian Streinu; Daniela Manolache; Anca Streinu-Cercel; Oana Sandulescu; Ana Blanaru; Monica Stoica; Ana Maria Andone; Daniela Dospinoiu; Silviu Serban; Loredana Patru; Christina Buhuara; Ramona Dorobantu; Magdalena Motoi; Ioana Daramus; George Bihoi; Alexandra Ghita; Victor Miron; Gylda Spataru; Amesika Nyaku; Shobha Swaminathan; Terence Chang; Robbyn Traylor; Lenee Gordon; John McDivitt; Lizette Castro; Douglas Young; Gary Carson; Angelica Kottkamp; Mark J. Mulligan; Anna Bershteyn; Vanessa Raabe; Tamia Davis; Mary Olson; Seuli Brill; Carlos Malvestutto; Susan Koletar; Taru Saigal; Mahdee Sobhanie; Vignesh Doraiswamy; Mahrous Abo Hassan; Jeremy Young; Edwin DeJesus; Charlotte-Paige Rolle; Federico Hinestrosa; Dan Cruz; Terry Wilder; Jeffrey Garrett; Stephanie Skipper; Ramprasad Dandillaya; Kartik Ananth; Ian Frank; Helen Koenig; Eileen Donaghy; Debora Dunbar; Jennifer Killion; Rupal Amin; Shauna Basener; Timothy Lowry; Kevin Cannon; Mesha Chadwick; Oscar Galvez; Fausto Castillo; John Jefferies; Sandy Arnold; Amber Thacker; Edward Cordasco; Brian Zeno; Heather Holmes; Heather Lee; Natalia Gaibu; Victor Cojocaru; Aristia Seremet; Sergiu Iacob; Rodica Usatii; Nelea Ghicavii; Angela Coltuclu; Oxana Bujor; Eleftherios Mylonakis; Dimitrios Farmakiotis; Karen Tashima; Natasha Ryback; Peter Ruane; Peter Wolfe; Kenny Trinidad; James Moy; Raj Shah; Bandi Sindhura; Beverly Sha; Mark Savant; Francis Hsiao; Edna Yee; Manuel Gordillo; Rishi Bhattacharyya; Sudha Tallapragada; Annette Artau; Julie Larkin; Roberto Mercado; Michael Milam; Natan Kraitman; Michael Lowry; Sarah Temple; Lenka Offner; Rabih Loutfi; Kirk Voelker; Marshall Frank; Ashley Grant; James Sims III; Manuel Vasquez; Kenneth Degazon; Katherine Asuncion; Jason Andrews; Aruna Subramanian; Upinder Singh; Yvonne Maldonado; Chaitan Khosla; Esteban Olivera; Mayra Abreu; Adil Fatakia; Marissa Miller; Kristen Clinton; Gary Reiss; Srilatha Edupuganti; Nadine Rouphael; Colleen Kelley; Varun Phadke; Cassie Grimsley Ackerley; Matthew Collins; Loren Miller; Timothy Hatlen; Michael Chung; Valeria Cantos Lucio; Carlos del Rio; Jeffrey Lennox; Sheetal Kandiah; Caitlin Moran; Anandi Sheth; Paulina Rebolledo; Nithin Gopalsamy; Divya Bhamidipati; Olayemi Osiyemi; Jose A. Menajovsky-Chaves; Christina Campbell; Andrew Strand; Andreas Klein; Debra Poutsiaka; Roberto Viau Colindres; Brian Chow; Cheleste Thorpe; Mary Hopkins; Jenn Chow; Rakhi Kohli; Jose Caro; Jeffrey Griffiths; Helen Boucher; Whitney Perry; Laura Kogelman; Yoav Golan; Tine Vindenes; Carlos Mendoza; Saba Mostafavi; Christhian Alejandro Cano Guerra; Paula Dabenigno; Bipin Malla; Dahlene Fusco; Arnaud Drouin; Joshua Denson; Jerry Zifodya; Christine Bojanowski; Monika Dietrich; Stacy Drury; Jesica Herrick; Richard Novak; Mahesh Patel; Gerard Acloque; Agustin Martinez; Sanjay Sethi; Brian Clemency; Rajesh Kunadharaju; Sairam Parthasarathy; Franz Rischard; Stuart Cohen; George Thompson; Hien Nguyen; Scott Crabtree; Carl Fichtenbaum; Moises Huaman; Jaime Robertson; Eric A. F. Simões; Thomas Campbell; Poornima Ramanan; Hillary Dunlevy; Esther Benamu; Amiran Baduashvili; Martin Krsak; Steven Johnson; Lakshmi Chauhan; Erica Fredregil; Samantha Economos; Brian T. Montague; Rowena Crow; Gary Kleiner; Lilian Abbo; Bhavarth Shukla; Jennifer Gebbia; Maria Rodriguez; Anne-Marie Leuck; Mahsa Abassi; Matthew Pullen; Jose Lucar Lloveras; Leandro Mena; Luis Shimose Ciudad; Jessica Lin; David Wohl; William Fischer II ; Kathleen Tompkins; Kami Kim; Seetha Lakshmi; Charurut Somboonwit; Jason Wilson; Asa Oxner; Tiffany Vasey; Lucy Guerra; William Petri; Katie Dykstra; Marianne Morrissey; Lejla Cesko; Jae Shin; Cirle Warren; Jennifer Sasson; Chelsea Marie; Debbie-Ann Shirley; Rebecca Carpenter; Gregory Madden; Danielle Donigan; Michelle Sutton; Cynthia Edwards; Elizabeth Brooks; Rebecca Wade; Samantha Simmons; Jennifer Pinnata; Shelly Karuna; Ann C. Collier; Julie McElrath; Janine Maenza; Adrienne Shapiro; Helen Stankiewicz-Karita; Helen Chu; Chandler Church; William Hartman; Joseph Connor; Robert Striker; Julie Philley; Megan Devine; Richard Yates; Steven Hickerson; Spyros Kalams; Greg Wilson; Michael Donnenberg; Marjolein de Wit; David Erb; Luis DeLaCruz; Supinder Channa; Sarah Henn; Megan Coleman; Lynsay MacLaren; Deborah Goldstein; Alice Eggleston; Carrington Koebele; Mark McKenzie; Teresa Deese; Benjamin Thomas; Laura Tsakiris; Stephen Blank; Ronald Mirenda; Anna Martin; Gargi Gharat; Candace Kokaram; Ket Wray; Clement Partap; Ulyana Arzamasova; Kristina Louissaint; Maria Fernandez; Achint Chani; Adebiyi Adepoju; Aisha Mortagy; Ajla Dupljak; Alison Brown; Amy Froment; Andrea Margiotta; Andrew Bombardier; Anita Islam; Anne Smith; Arvinder Dhillon; Audra McMillian; Aurora Breazna; Ayesha Aslam; Barabara Carpentino; Barry Siliverstein; Benjamin Horel; Bo Zhu; Brian Bush; Brian Head; Brian Snow; Bryan Zhu; Camille Debray; Careta Phillips; Carmella Simiele; Carol Lee; Carolyn Nienstedt; Caryn Trbovic; Catherine Elliott; Chad Fish; Charlie Ni; Christa Polidori; Christine Enciso; Christopher Caira; Christopher Powell; Cliff Baum; Colin McDonald; Cynthia Leigh; Cynthia Pan; Dana Wolken; Danielle Manganello; David Liu; David Stein; Dawlat Hassan; Daya Gulabani; Deborah Fix; Deborah Leonard; Deepshree Sarda; Denise Bonhomme; Denise Kennedy; Devin Darcy; Dhanalakshmi Barron; Diana Hughes; Diana Rofail; Dipinder Kaur; Dona Bianco; Donna Cohen; Edward Jean-Baptiste; Ehsan Bukhari; Eileen Doyle; Elizabeth Bucknam; Emily Labriola-Tomkins; Emily Nanna; Esther Huffman O'Keefe; Evelyn Gasparino; Evonne Fung; Fung-Yee To; Georgia Bellingham; Giane Sumner; Grainne Moggan; Grainne Power; Haixia Zeng; Hazel Mariveles; Heath Gonzalez; Helen Kang; Hibo Noor; Ian Minns; Izabella Peszek; James Donohue; Jamie Rusconi; Janice Austin; Janie Parrino; Jeannie Yo; Jenna McDonnell; Jessica Boarder; Jianguo Wei; Jingchun Yu; Joanne Malia; Joanne Tucciarone; Jodie Tyler-Gale; John Strein; Jonathan Cohen; Jonathan Meyer; Jordan Ursino; Joseph Im; Joseph Tramaglini; Joseph Wolken; Kaitlyn Potter; Kaitlyn Scacalossi; Kamala Naidu; Karen Browning; Karen Rutkowski; Karen Yau; Katherine Woloshin; Kelly Lewis-Amezcua; Kimberly Dornheim; Kit Chiu; Kosalai Mohan; Kristina McGuire; Kristy Macci; Kurt Ringleben; Kusha Mohammadi; Kyle Foster; Latora Knighton; Lindsay Darling; Lisa Boersma; Lisa Cowen; Lisa Hersh; Lisa Jackson; Lisa Sherpinsky; Livia Lai; Lori Faria; Lori Geissler; Louise Boppert; Lyra Fiske; Marc Dickens; Marco Mancini; Maria C. Leigh; Michael Batchelder; Michael Klinger; Michael Partridge; Michel Tarabocchia; Michelle Wong; Mivianisse Rodriguez; Moetaz Albizem; Muriel O'Byrne; Nicole Deitz; Nicole Memblatt; Nirav Shah; Nitin Kumar; Olga Herrera; Oluchi Adedoyin; Ori Yellin; Pamela Snodgrass; Patrick Floody; Paul D'Ambrosio; Paul (Xiaobang) Gao; Philippa Hearld; Qin Li; Rachel Kitchenoff; Rakiyya Ali; Ramya Iyer; Ravikanth Chava; Rinol Alaj; Rita Pedraza; Robert Hamlin; Romana Hosain; Ruchin Gorawala; Ryan White; Ryan Yu; Rylee Fogarty; S. Balachandra Dass; Sagarika Bollini; Samit Ganguly; Sandra DeCicco; Sanket Patel; Sarah Cassimaty; Selin Somersan-Karakaya; Shane McCarthy; Sharon Henkel; Shazia Ali; Shelley Geila Shapiro; Somang Kim; Soraya Nossoughi; Stephanie Bisulco; Steven Elkin; Steven Long; Sumathi Sivapalasingam; Susan Irvin; Susan Wilt; Tami Min; Tatiana Constant; Theresa Devins; Thomas Norton; Travis Bernardo; Tzu-Chien Chuang; Victor (Jianguo) Wei; Vinh Nuce; Vishnu Battini; Wilson Caldwell; Xiaobang Gao; Xin Chen; Yanmei Tian; Yasmin Khan; Yuming Zhao; Bonnie Dye; David Burns; Meredith Clement; Nirupama Sista; Sheryl Zwerski