A nosocomial outbreak of severe acute respiratory syndrome (SARS) (caused by SARS-CoV-1) occurred at the Kaohsiung Chang Gung Memorial Hospital (KCGMH) in 2003.1 Sixteen health care workers (HCWs) had SARS-CoV-1 infection.1 In 2021, a community outbreak of SARS-CoV-2 occurred in Taiwan.2 It is potentially possible that individuals with prior SARS-CoV-1 infection were protected from infection. If so, antibody levels after vaccination might be higher than in individuals who did not have SARS-CoV-1 infection. This study assessed antibody levels after ChAdOx1 nCoV-19 vaccination (AstraZeneca) in individuals with previous SARS-CoV-1 infection compared with uninfected individuals who received ChAdOx1 vaccination.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: November 14, 2021.
Published Online: January 24, 2022. doi:10.1001/jamainternmed.2021.7679
Corresponding Author: Ing-Kit Lee, MD, School of Medicine, College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan District, Taoyuan City 33302, Taiwan, Republic of China (firstname.lastname@example.org).
Author Contributions: Drs Chen and Lee had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Chen, Lu, Wang.
Acquisition, analysis, or interpretation of data: Chen, Lu, You, Lee.
Drafting of the manuscript: Chen, Lu, Lee.
Critical revision of the manuscript for important intellectual content: Lu, You, Wang, Lee.
Statistical analysis: Lu, Lee.
Obtained funding: Lu.
Administrative, technical, or material support: Lu, Wang.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by the Chang Gung Memorial Hospital (grant CORPG8L0611).
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
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