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Vaccination

SARS-CoV-2 Antibody Response After ChAdOx1 nCoV-19 Vaccination in Persons With Previous SARS-CoV-1 Infection

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To identify the key insights or developments described in this article

1 Credit CME

JAMA Internal Medicine

Published Online: January 24, 2022

Research Letter

Article Information and Disclosures

Yi-Chun Chen, MD¹;

Sheng-Nan Lu, MD, PhD²;

Huey-Ling You, PhD, MT³;

Chih-Chi Wang, MD⁴;

Ing-Kit Lee, MD⁵

Author Affiliations

¹Division of Infectious Diseases, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
²Division of Hepatogastroenterology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
³Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
⁴Department of General Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
⁵School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China

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A nosocomial outbreak of severe acute respiratory syndrome (SARS) (caused by SARS-CoV-1) occurred at the Kaohsiung Chang Gung Memorial Hospital (KCGMH) in 2003.¹ Sixteen health care workers (HCWs) had SARS-CoV-1 infection.¹ In 2021, a community outbreak of SARS-CoV-2 occurred in Taiwan.² It is potentially possible that individuals with prior SARS-CoV-1 infection were protected from infection. If so, antibody levels after vaccination might be higher than in individuals who did not have SARS-CoV-1 infection. This study assessed antibody levels after ChAdOx1 nCoV-19 vaccination (AstraZeneca) in individuals with previous SARS-CoV-1 infection compared with uninfected individuals who received ChAdOx1 vaccination.

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Article Information

Accepted for Publication: November 14, 2021.

Published Online: January 24, 2022. doi:10.1001/jamainternmed.2021.7679

Corresponding Author: Ing-Kit Lee, MD, School of Medicine, College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan District, Taoyuan City 33302, Taiwan, Republic of China (leee@cgmh.org.tw).

Author Contributions: Drs Chen and Lee had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Chen, Lu, Wang.

Acquisition, analysis, or interpretation of data: Chen, Lu, You, Lee.

Drafting of the manuscript: Chen, Lu, Lee.

Critical revision of the manuscript for important intellectual content: Lu, You, Wang, Lee.

Statistical analysis: Lu, Lee.

Obtained funding: Lu.

Administrative, technical, or material support: Lu, Wang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by the Chang Gung Memorial Hospital (grant CORPG8L0611).

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.