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SARS-CoV-2 Antibody Response After ChAdOx1 nCoV-19 Vaccination in Persons With Previous SARS-CoV-1 Infection

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To identify the key insights or developments described in this article
1 Credit CME

A nosocomial outbreak of severe acute respiratory syndrome (SARS) (caused by SARS-CoV-1) occurred at the Kaohsiung Chang Gung Memorial Hospital (KCGMH) in 2003.1 Sixteen health care workers (HCWs) had SARS-CoV-1 infection.1 In 2021, a community outbreak of SARS-CoV-2 occurred in Taiwan.2 It is potentially possible that individuals with prior SARS-CoV-1 infection were protected from infection. If so, antibody levels after vaccination might be higher than in individuals who did not have SARS-CoV-1 infection. This study assessed antibody levels after ChAdOx1 nCoV-19 vaccination (AstraZeneca) in individuals with previous SARS-CoV-1 infection compared with uninfected individuals who received ChAdOx1 vaccination.

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Article Information

Accepted for Publication: November 14, 2021.

Published Online: January 24, 2022. doi:10.1001/jamainternmed.2021.7679

Corresponding Author: Ing-Kit Lee, MD, School of Medicine, College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan District, Taoyuan City 33302, Taiwan, Republic of China (leee@cgmh.org.tw).

Author Contributions: Drs Chen and Lee had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Chen, Lu, Wang.

Acquisition, analysis, or interpretation of data: Chen, Lu, You, Lee.

Drafting of the manuscript: Chen, Lu, Lee.

Critical revision of the manuscript for important intellectual content: Lu, You, Wang, Lee.

Statistical analysis: Lu, Lee.

Obtained funding: Lu.

Administrative, technical, or material support: Lu, Wang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by the Chang Gung Memorial Hospital (grant CORPG8L0611).

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Liu  JW , Lu  SN , Chen  SS ,  et al.  Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory syndrome in a medical center in Kaohsiung, Taiwan.   Infect Control Hosp Epidemiol. 2006;27(5):466-472. doi:10.1086/504501 PubMedGoogle ScholarCrossref
2.
Taiwan Centers for Disease Control. Taiwan National Infectious Disease Statistics System. Accessed September 21, 2021. https://nidss.cdc.gov.tw/nndss/DiseaseMap?id=19CoV
3.
Lee  IK , Wang  CC , Lin  MC , Kung  CT , Lan  KC , Lee  CT .  Effective strategies to prevent coronavirus disease-2019 (COVID-19) outbreak in hospital.   J Hosp Infect. 2020;105(1):102-103. doi:10.1016/j.jhin.2020.02.022 PubMedGoogle ScholarCrossref
4.
Le Bert  N , Tan  AT , Kunasegaran  K ,  et al.  SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.   Nature. 2020;584(7821):457-462. doi:10.1038/s41586-020-2550-z PubMedGoogle ScholarCrossref
5.
Tseng  WP , Wu  JL , Wu  CC ,  et al.  Seroprevalence surveys for anti-SARS-CoV-2 antibody in different populations in Taiwan with low incidence of COVID-19 in 2020 and severe outbreaks of SARS in 2003.   Front Immunol. 2021;12(12):626609. doi:10.3389/fimmu.2021.626609PubMedGoogle Scholar
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Khoury  DS , Cromer  D , Reynaldi  A ,  et al.  Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.   Nat Med. 2021;27(7):1205-1211. doi:10.1038/s41591-021-01377-8 PubMedGoogle ScholarCrossref
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