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Infectious Diseases

Evaluation of Antimicrobial Drug Use and Concurrent Infections During Hospitalization of Patients With COVID-19 in Japan

Educational Objective
To identify the key insights or developments described in this article

1 Credit CME

JAMA Network Open

Published Online: February 18, 2022

Research Letter

Article Information and Disclosures

Junpei Komagamine, MD¹;

Taku Yabuki, MD¹;

Kohei Matsumoto, MD¹;

Nao Tanaka, MD¹

Author Affiliations

¹Department of Internal Medicine, National Hospital Organization Tochigi Medical Center, Nakatomatsuri, Utsunomiya, Tochigi, Japan

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A recent meta-analysis¹^,2 and a prospective study³ reported that bacterial coinfection and secondary infection among patients with COVID-19 infection are uncommon. However, in these studies, antimicrobial drugs were prescribed for approximately 70% of patients with the disease.² Therefore, data are needed on patients with COVID-19 infection who do not routinely receive an antimicrobial drug prescription, to identify the true rate of concurrent infection in this patient population. At the National Hospital Organization Tochigi Medical Center in Utsunomiya, Tochigi, Japan, since the beginning of the COVID-19 pandemic, antimicrobial drugs have not been prescribed for patients with COVID-19 infection unless their symptoms are suggestive of another infectious disease. Therefore, we investigated the prevalence of antimicrobial drug use and concurrent infections among patients with COVID-19 during hospitalization.

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Article Information

Accepted for Publication: December 30, 2021.

Published: February 18, 2022. doi:10.1001/jamanetworkopen.2022.0040

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Komagamine J et al. JAMA Network Open.

Corresponding Author: Junpei Komagamine, MD, Department of Internal Medicine, National Hospital Organization Tochigi Medical Center, 1-10-37 Nakatomatsuri, Utsunomiya, Tochigi, Japan (junpei0919@yahoo.co.jp).

Author Contributions: Dr Komagamine had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Komagamine, Yabuki.

Acquisition, analysis, or interpretation of data: Komagamine, Matsumoto, Tanaka.

Drafting of the manuscript: Komagamine.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Komagamine.

Supervision: Komagamine, Yabuki.

Conflict of Interest Disclosures: None reported.

Meeting Presentation: Data from this study will be used at a poster presentation at the 119th Annual Meeting of the Japanese Society of Internal Medicine, April 15-17, 2022; virtual.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.