COVID-19 has had a major impact on all countries and regions globally. The populations where randomized clinical trials (RCTs) have been conducted may not reflect the burden of disease.1,2
In this systematic review, we evaluated the proportion of participants recruited in RCTs for COVID-19 from low- and middle-income (LMIC) countries compared with high-income countries (HIC) (using World Bank definitions) relative to disease burden in these regions. We also examined these proportions stratified by COVID-19 vaccine and nonvaccine RCTs. We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: January 07, 2021.
Published: February 25, 2022. doi:10.1001/jamanetworkopen.2022.0444
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Ramanan M et al. JAMA Network Open.
Corresponding Author: Steven Y. C. Tong MBBS, PhD, Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC, Australia (firstname.lastname@example.org).
Author Contributions: Drs Ramanan and Tong had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Ramanan, Tong, Venkatesh.
Acquisition, analysis, or interpretation of data: Ramanan, Tong, Kumar.
Drafting of the manuscript: Ramanan, Tong, Venkatesh.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ramanan.
Administrative, technical, or material support: Ramanan.
Supervision: Tong, Venkatesh.
Conflict of Interest Disclosures: Dr Tong reported receiving grants from the National Health and Medical Research Council Career Development Fellowship during the conduct of the study. Dr Venkatesh reported receiving institutional research support from Baxter Health Care outside the submitted work; and an Investigator Fellowship from the National Health and Medical Research Council, Australia. No other disclosures were reported.
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Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
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