Corresponding Author: Elie Azoulay, MD, PhD, Médecine Intensive et Réanimation, APHP, Hôpital Saint-Louis, Paris University, 1 Avenue Claude Vellefaux, 75010 Paris, France (elie.azoulay@aphp.fr).
Accepted for Publication: February 2, 2022.
Published Online: February 18, 2022. doi:10.1001/jama.2022.2017
Author Contributions: Drs Azoulay and Resche-Rigon had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Azoulay, Resche-Rigon, Geri, Quenot, Lesieur, Demoule, Guitton, Biard, Pochard, Kentish-Barnes.
Acquisition, analysis, or interpretation of data: Azoulay, Megarbane, Reuter, Labbé, Cariou, Geri, Van der Meersch, Kouatchet, Guisset, Bruneel, Reignier, Souppart, Barbier, Argaud, Quenot, Papazian, Guidet, Thiéry, Klouche, Lesieur, Demoule, Guitton, Capellier, Mourvillier, Biard, Pochard, Kentish-Barnes.
Drafting of the manuscript: Azoulay, Resche-Rigon, Quenot, Lesieur, Biard, Pochard, Kentish-Barnes.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Resche-Rigon, Lesieur, Demoule, Biard.
Obtained funding: Azoulay, Resche-Rigon.
Administrative, technical, or material support: Resche-Rigon, Souppart, Lesieur, Guitton, Mourvillier.
Supervision: Azoulay, Guisset, Bruneel, Quenot, Guidet, Thiéry, Klouche, Lesieur, Guitton, Capellier, Mourvillier, Pochard, Kentish-Barnes.
Conflict of Interest Disclosures: Dr Azoulay reported receipt of personal fees (lectures) from Pfizer, Gilead, Baxter, and Alexion; and institutional research grants from Merck Sharp and Dohme, Pfizer, Baxter, and Alexion outside the submitted work. Dr Labbé reported personal fees from Amomed and grants from LeoPharma outside the submitted work. Dr Cariou reported personal fees from Bard outside the submitted work. Dr Souppart reported grants from French Ministry of Health during the conduct of the study. Dr Barbier reported personal fees from Merck Sharp and Dohme and BioMérieux outside the submitted work. Dr Papazian reported personal fees from Air Liquide Santé and Gettinge and grants from SEDANA outside the submitted work. Dr Thiéry reported personal fees from Amgen outside the submitted work. Dr Demoule reported grants from the French Ministry of Health; grants and personal fees from Philips, Fisher & Paykel, Respinor, and Lungpacer; personal fees from Baxter, Getinge, Gilead, and Lowenstein; and nonfinancial support from Fisher & Paykel outside the submitted work. Dr Capellier reported grants from ASTEN and Baxter; other from Freysenius (conference fees); and personal fees from ARCHEON outside the submitted work. Dr Kentish-Barnes reported grants from French Ministry of Health during the conduct of the study and outside the submitted work. No other disclosures were reported.
Funding/Support: All financial support for the research was provided by the French Ministry of Health.
Role of the Funder/Sponsor: The French Ministry of Health had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank all members of the team from the clinical research unit of the Saint-Louis Hospital: Anne-Juliette Trouiller, MS (senior research assistant), El Mountacer El Abassi, PhD (project manager), Marine Cognat, MS (research coordinator), Zakaria Maakoul, MS (research coordinator), Amine Hanachi, MS (research coordinator), Malika Ghartouchant, MS (research coordinator), and Fatima Ait Seddik, MS (research coordinator); and members from the critical care department of the Saint-Louis Hospital: Philonille Degos, MS, and Clémence Viau, MS, for their help and engagement in the study. None of these individuals received a dedicated compensation for their role in the study.
Additional Information: This study was performed on behalf of the Famirea Study Group.