Association of COVID-19 Infection With Survival After In-Hospital Cardiac Arrest Among US Adults | Cardiology | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Association of COVID-19 Infection With Survival After In-Hospital Cardiac Arrest Among US Adults

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Early on in the COVID-19 pandemic, investigators reported poor survival rates (<3%) after in-hospital cardiac arrest (IHCA) among patients with COVID-19 infection in the US and China.13 These findings have prompted discussions regarding universal do-not-resuscitate orders for patients with COVID-19.4 However, these results were from single-center studies that comprised only 295 patients with COVID-19 in hospitals that were overwhelmed early during the pandemic. Whether the poor IHCA survival rate reported in earlier studies is broadly representative of patients with COVID-19 in US hospitals remains unknown. This study examined the association of COVID-19 infection with survival outcomes of US adults after IHCA.

Sign in to take quiz and track your certificates

Buy This Activity

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: January 12, 2022.

Published: March 2, 2022. doi:10.1001/jamanetworkopen.2022.0752

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Girotra S et al. JAMA Network Open.

Corresponding Author: Saket Girotra, MD, SM, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242 (saket-girotra@uiowa.edu).

Author Contributions: Drs Girotra and P.S. Chan had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Girotra, Starks, P.S. Chan.

Acquisition, analysis, or interpretation of data: Girotra, M.L. Chan, Churpek, P.S. Chan.

Drafting of the manuscript: Girotra, M.L. Chan.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: M.L. Chan.

Supervision: Girotra.

Conflict of Interest Disclosures: Dr Girotra reported receiving grants from the National Heart, Lung, and Blood Institute (NHLBI) outside the submitted work and receiving an honorarium from the American Heart Association for editorial work outside the submitted work. Dr Starks reported receiving grants from the NHLBI outside the submitted work. Dr Churpek reported receiving research support from EarlySense and grants from the NHLBI, the National Institute on Aging, the National Institute on Drug Abuse, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of General Medical Sciences, and the Department of Defense Peer-Reviewed Medical Research Program outside the submitted work and having a patent pending (ARCD.P0535US.P2) for risk stratification algorithms for hospitalized patients. Dr P.S. Chan reported receiving grants from NHLBI outside the submitted work and receiving consultant funding from the American Heart Association and OptumRx. No other disclosures were reported.

The American Heart Association Get With the Guidelines–Resuscitation Investigators: Dana Edelson, MD, MS (University of Chicago); Zachary Goldberger, MD, MS (University of Wisconsin); Anne Grossestreuer, PhD (Beth Israel Deaconness Medical Center and Harvard Medical School); Michael Kurcz, MD (University of Alabama); Ari Moskowitz, MD (Beth Israel Deaconness Medical Center and Harvard Medical School); Joseph Ornato, MD (Virginia Commonwealth University); Mary Ann Peberdy, MD (Virginia Commonwealth University); Sarah Perman, MD, MSCE (University of Colorado).

Additional Information: The Get With the Guidelines (GWTG) programs are provided by the American Heart Association. Hospitals participating in the registry submit clinical information regarding the medical history, hospital care, and outcomes of consecutive patients hospitalized for cardiac arrest using an online, interactive case report form and the IQVIA Patient Management Tool. IQVIA serves as the data collection and coordination center for the American Heart Association/American Stroke Association GWTG programs. The University of Pennsylvania serves as the data analytic center and has an agreement to prepare the data for research purposes.

References
1.
Thapa  SB , Kakar  TS , Mayer  C , Khanal  D .  Clinical outcomes of in-hospital cardiac arrest in COVID-19.   JAMA Intern Med. 2021;181(2):279-281. doi:10.1001/jamainternmed.2020.4796 PubMedGoogle ScholarCrossref
2.
Shao  F , Xu  S , Ma  X ,  et al.  In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China.   Resuscitation. 2020;151:18-23. doi:10.1016/j.resuscitation.2020.04.005 PubMedGoogle ScholarCrossref
3.
Miles  JA , Mejia  M , Rios  S ,  et al.  Characteristics and outcomes of in-hospital cardiac arrest events during the COVID-19 pandemic: a single-center experience from a New York City public hospital.   Circ Cardiovasc Qual Outcomes. 2020;13(11):e007303. doi:10.1161/CIRCOUTCOMES.120.007303 PubMedGoogle Scholar
4.
Cha  AE .  Hospitals consider universal do-not-resuscitate orders for coronavirus patients.  Washington Post. March 25, 2020. Accessed July 27, 2021. http://www.washingtonpost.com/health/2020/03/25/coronavirus-patients-do-not-resucitate
5.
Hayek  SS , Brenner  SK , Azam  TU ,  et al; STOP-COVID Investigators.  In-hospital cardiac arrest in critically ill patients with COVID-19: multicenter cohort study.   BMJ. 2020;371:m3513. doi:10.1136/bmj.m3513 PubMedGoogle Scholar
6.
Mitchell  OJL , Yuriditsky  E , Johnson  NJ ,  et al; Coronavirus 2019 In-Hospital Cardiac Arrest (COVID IHCA) Study Group.  In-hospital cardiac arrest in patients with coronavirus 2019.   Resuscitation. 2021;160:72-78. doi:10.1016/j.resuscitation.2021.01.012 PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close