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Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel

Educational Objective
To identify the key insights or developments described in this article

Vaccination has limited SARS-CoV-2 spread and prevented major illness and death during the COVID-19 pandemic.1 However, certain adverse events, such as an increased incidence of myocarditis, particularly in young men, have been associated with vaccination with the BNT162b2 mRNA vaccine (Pfizer-BioNTech).2,3

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Article Information

Accepted for Publication: March 9, 2022.

Published Online: March 17, 2022. doi:10.1001/jama.2022.4425

Corresponding Author: Limor Friedensohn, MD, Israel Defense Forces, Medical Corps Headquarters, Tel Hashomer, Ramat Gan, Israel (limor.fri@gmail.com).

Author Contributions: Drs Friedensohn and Gordon had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Friedensohn and Levin contributed equally.

Concept and design: Friedensohn, Fadlon-Derai, Fink, Gordon.

Acquisition, analysis, or interpretation of data: Friedensohn, Levin, Gershovitz, Glassberg, Gordon.

Drafting of the manuscript: Friedensohn, Levin, Gershovitz, Gordon.

Critical revision of the manuscript for important intellectual content: Friedensohn, Fadlon-Derai, Fink, Glassberg, Gordon.

Statistical analysis: Gordon.

Administrative, technical, or material support: Friedensohn, Levin, Fadlon-Derai, Gershovitz, Glassberg.

Supervision: Friedensohn, Fink, Glassberg, Gordon.

Conflict of Interest Disclosures: None reported.

References
1.
Bar-On  YM , Goldberg  Y , Mandel  M ,  et al.  Protection of BNT162b2 vaccine booster against COVID-19 in Israel.   N Engl J Med. 2021;385(15):1393-1400. doi:10.1056/NEJMoa2114255PubMedGoogle ScholarCrossref
2.
Shay  DK , Shimabukuro  TT , DeStefano  F .  Myocarditis occurring after immunization with mRNA-based COVID-19 vaccines.   JAMA Cardiol. 2021;6(10):1115-1117. doi:10.1001/jamacardio.2021.2821PubMedGoogle ScholarCrossref
3.
Oster  ME , Shay  DK , Su  JR ,  et al.  Myocarditis cases reported after mRNA-based COVID-19 vaccination in the US from December 2020 to August 2021.   JAMA. 2022;327(4):331-340. doi:10.1001/jama.2021.24110PubMedGoogle ScholarCrossref
4.
Levin  D , Shimon  G , Fadlon-Derai  M ,  et al.  Myocarditis following COVID-19 vaccination: a case series.   Vaccine. 2021;39(42):6195-6200. doi:10.1016/j.vaccine.2021.09.004PubMedGoogle ScholarCrossref
5.
Mevorach  D , Anis  E , Cedar  N ,  et al.  Myocarditis after BNT162b2 mRNA vaccine against COVID-19 in Israel.   N Engl J Med. 2021;385(23):2140-2149. doi:10.1056/NEJMoa2109730PubMedGoogle ScholarCrossref
6.
Diaz  GA , Parsons  GT , Gering  SK , Meier  AR , Hutchinson  IV , Robicsek  A .  Myocarditis and pericarditis after vaccination for COVID-19.   JAMA. 2021;326(12):1210-1212. doi:10.1001/jama.2021.13443PubMedGoogle ScholarCrossref
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