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Obstetrics and Gynecology

Attitudes and Beliefs Associated With COVID-19 Vaccination During Pregnancy

Educational Objective
To identify the key insights or developments described in this article

1 Credit CME

JAMA Network Open

Published Online: April 14, 2022

Research Letter

Article Information and Disclosures

Yiwen Cui, MD¹;

Kole Binger, BS²;

Anna Palatnik, MD¹

Author Affiliations

¹Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee
²Medical College of Wisconsin, Milwaukee

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Pregnant people with SARS-CoV-2 infection have obstetric and medical complications during and after pregnancy.¹ Receiving COVID-19 vaccine reduces these complications by 90%.² However, vaccine uptake in pregnancy remains low. As of January 15, 2022, only 42.6% of pregnant people were fully vaccinated, with 24.4% receiving at least 1 vaccine dose during pregnancy.³ To address this public health challenge, we designed and validated a survey to identify strategies to address vaccine-hesitancy in pregnant people. The objective of this study was to investigate which maternal self-reported attitudes and beliefs are associated with COVID-19 vaccine uptake during pregnancy.

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Article Information

Accepted for Publication: February 25, 2022.

Published: April 14, 2022. doi:10.1001/jamanetworkopen.2022.7430

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Cui Y et al. JAMA Network Open.

Corresponding Author: Anna Palatnik, MD, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226 (apalatnik@mcw.edu).

Author Contributions: Dr Palatnik had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Cui, Palatnik.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Cui.

Administrative, technical, or material support: Binger, Palatnik.

Supervision: Cui, Palatnik.

Conflict of Interest Disclosures: Dr Palatnik reported grants from the American Heart Association and grants from Advancing Healthier Wisconsin/Medical College of Wisconsin Clinical and Translational Science Institute outside the submitted work. No other disclosures were reported.

Funding/Support: Dr Palatnik is supported by the American Heart Association Career Development Award 847482.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Meeting Presentation: This paper was presented, in part, at the 42nd Annual Pregnancy Meeting of the Society for Maternal-Fetal Medicine; January 31 to February 5, 2022; virtual.

References:

Metz TD , Clifton RG , Hughes BL , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-580. doi:10.1097/AOG.0000000000004339 PubMed Google Scholar Crossref

Morgan JA , Biggio JR Jr , Martin JK , et al. Maternal outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vaccinated compared with unvaccinated pregnant patients. Obstet Gynecol. 2022;139(1):107-109. doi:10.1097/AOG.0000000000004621 PubMed Google Scholar Crossref

CDC. Percent of pregnant people aged 18-49 years receiving at least one dose of a COVID-19 vaccine during pregnancy overall, by race/ethnicity, and date reported to CDC – Vaccine Safety Datalink, United States. Accessed January 22, 2022. https://covid.cdc.gov/covid-data-tracker/#vaccinations-pregnatn-women

Charepe N , Gonçalves J , Juliano AM , et al. COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study. BMC Pregnancy Childbirth. 2021;21(1):632. doi:10.1186/s12884-021-04051-6 PubMed Google Scholar Crossref

Nir O , Schwartz A , Toussia-Cohen S , et al. Maternal-neonatal transfer of SARS-CoV-2 immunoglobulin G antibodies among parturient women treated with BNT162b2 messenger RNA vaccine during pregnancy. Am J Obstet Gynecol MFM. 2022;4(1):100492. doi:10.1016/j.ajogmf.2021.100492 PubMed Google Scholar

Jorgensen SCJ , Burry L , Tabbara N . Role of maternal COVID-19 vaccination in providing immunological protection to the newborn. Pharmacotherapy. 2022;42(1):58-70. doi:10.1002/phar.2649 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.