Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2—A Report From the US National COVID Cohort Collaborative | Pediatrics | JN Learning | AMA Ed Hub [Skip to Content]
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Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2—A Report From the US National COVID Cohort Collaborative

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

SARS-CoV-2 can cause severe pediatric disease, including acute COVID-19 and multisystem inflammatory syndrome.1 Published reports associating SARS-CoV-2 with upper airway infection (UAI), such as laryngotracheobronchitis (croup), have been limited to small case series.2 Although noncoronaviruses, including parainfluenza and respiratory syncytial virus, most frequently cause UAI, coronaviruses (eg, type NL63) are also commonly implicated. Young children are especially vulnerable to UAI given their small and relatively collapsible airways.

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Article Information

Accepted for Publication: March 9, 2022.

Published Online: April 15, 2022. doi:10.1001/jamapediatrics.2022.1110

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Martin B et al. JAMA Pediatrics.

Corresponding Author: Blake Martin, MD, Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, 13123 E 16th Ave, Aurora, CO 80045 (blake.martin@cuanschutz.edu).

Author Contributions: Dr Martin had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Martin, Haendel, Bennett.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Martin, DeWitt, Bennett.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Martin, DeWitt, Russell, Bennett.

Obtained funding: Haendel, Bennett.

Administrative, technical, or material support: Russell.

Supervision: Martin, Sanchez-Pinto, Moffitt, Bennett.

Conflict of Interest Disclosures: Dr Martin reports grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development during the conduct of the study and from Thrasher Research Fund Early Career Award outside the submitted work. Drs Sanchez-Pinto and Moffitt report grants from National Institutes of Health during the conduct of the study. Dr Bennett reports grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development during the conduct of the study and grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Heart, Lung, and Blood Institute, and the National Center for Advancing Translational Sciences outside the submitted work. No other disclosures were reported.

Funding/Support: This study was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD105939-01S1). Additionally, the analyses described in this publication were conducted with data or tools accessed through the NCATS N3C Data Enclave (covid.cd2h.org/enclave) and supported by NCATS U24 TR002306. This research was possible because of the patients whose information is included within the data from participating organizations (covid.cd2h.org/dtas) and the organizations and scientists (covid.cd2h.org/duas) who have contributed to the ongoing development of this community resource (https://doi.org/10.1093/jamia/ocaa196).

Role of the Funder/Sponsor: The Eunice Kennedy Shriver National Institute of Child Health and Human Development provided support for the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

References
1.
Martin  B , DeWitt  PE , Russell  S ,  et al.  Characteristics, outcomes, and severity risk factors associated with SARS-CoV-2 infection among children in the US national COVID cohort collaborative.   JAMA Netw Open. 2022;5(2):e2143151-e2143151. doi:10.1001/jamanetworkopen.2021.43151PubMedGoogle ScholarCrossref
2.
Venn  AMR , Schmidt  JM , Mullan  PC .  Pediatric croup with COVID-19.   Am J Emerg Med. 2021;43:287.e281-287.e283. doi:10.1016/j.ajem.2020.09.034PubMedGoogle ScholarCrossref
3.
Centers for Disease Control and Prevention. COVID Data Tracker: Variant Proportions. Accessed January 19, 2022. https://covid.cdc.gov/covid-data-tracker/#variant-proportions
4.
Chan  MC , Hui  KP , Ho  J ,  et al.  SARS-CoV-2 Omicron variant replication in human respiratory tract ex vivo.   Research Square. Preprint posted online December 22, 2021. doi:10.21203/rs.3.rs-1189219/v1Google Scholar
5.
Haendel  MA , Chute  CG , Bennett  TD ,  et al; N3C Consortium.  The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment.   J Am Med Inform Assoc. 2021;28(3):427-443.PubMedGoogle ScholarCrossref
6.
The National COVID Cohort Collaborative. N3C Pediatrics Dashboard. Accessed January 19, 2022. https://covid.cd2h.org/pediatrics-dashboard/
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