Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19 | Infectious Diseases | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Risk of SARS-CoV-2 reinfection among unvaccinated people with prior COVID-19 is a subject of debate.1,2 We performed a survival analysis in a large US population to assess the degree and duration of protection associated with natural immunity in unvaccinated individuals.

Sign in to take quiz and track your certificates

Buy This Activity

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: February 24, 2022.

Published: April 20, 2022. doi:10.1001/jamanetworkopen.2022.7650

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Ridgway JP et al. JAMA Network Open.

Corresponding Author: Jessica P. Ridgway, MD, Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC 5065, Chicago, IL 60637 (Jessica.ridgway@uchospitals.edu).

Author Contributions: Dr Robicsek had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Tideman, Wright, Robicsek.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Ridgway, Wright, Robicsek.

Critical revision of the manuscript for important intellectual content: Tideman, Wright, Robicsek.

Statistical analysis: Tideman, Robicsek.

Obtained funding: Robicsek.

Administrative, technical, or material support: Ridgway, Wright, Robicsek.

Supervision: Wright, Robicsek.

Conflict of Interest Disclosures: None reported.

References
1.
Chen  X , Chen  Z , Azman  AS ,  et al.  Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants induced by natural infection or vaccination: a systematic review and pooled analysis.   Clin Infect Dis. 2022;74(4):734-742. doi:10.1093/cid/ciab646PubMedGoogle ScholarCrossref
2.
Kojima  N , Klausner  JD .  Protective immunity after recovery from SARS-CoV-2 infection.   Lancet Infect Dis. 2022;22(1):12-14. doi:10.1016/S1473-3099(21)00676-9PubMedGoogle ScholarCrossref
3.
Hansen  CH , Michlmayr  D , Gubbels  SM , Mølbak  K , Ethelberg  S .  Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study.   Lancet. 2021;397(10280):1204-1212. doi:10.1016/S0140-6736(21)00575-4 PubMedGoogle ScholarCrossref
4.
Sheehan  MM , Reddy  AJ , Rothberg  MB .  Reinfection rates among patients who previously tested positive for coronavirus disease 2019: a retrospective cohort study.   Clin Infect Dis. 2021;73(10):1882-1886. doi:10.1093/cid/ciab234PubMedGoogle ScholarCrossref
5.
Thompson  MG , Burgess  JL , Naleway  AL ,  et al.  Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines.   N Engl J Med. 2021;385(4):320-329. doi:10.1056/NEJMoa2107058 PubMedGoogle ScholarCrossref
6.
Tartof  SY , Slezak  JM , Fischer  H ,  et al.  Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study.   Lancet. 2021;398(10309):1407-1416. doi:10.1016/S0140-6736(21)02183-8 PubMedGoogle ScholarCrossref
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close