Fresh Embryo Transfer Cycle Characteristics and Outcomes Following In Vitro Fertilization via Intracytoplasmic Sperm Injection Among Patients With and Without COVID-19 Vaccination | Vaccination | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Fresh Embryo Transfer Cycle Characteristics and Outcomes Following In Vitro Fertilization via Intracytoplasmic Sperm Injection Among Patients With and Without COVID-19 Vaccination

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Women of reproductive age have been at the forefront of COVID-19 vaccine hesitancy, citing concerns about the vaccine’s effect on future fertility, current pregnancy, and breastfeeding (among others).1 As of February 2022, only 57% of pregnant patients were fully vaccinated against COVID-19 prior to becoming pregnant, a rate that lags that of the general population.2 To date, current literature surrounding COVID-19 vaccination and potential associations with infertility have been performed mainly in frozen embryo transfer cycles or in vitro fertilization cycles (IVF) using intracytoplasmic sperm injection (ICSI), both of which do not occur in in vivo conception.3,4 The aim of this study was to investigate the association of COVID-19 vaccination status with IVF-fresh embryo transfer cycle stimulation characteristics and clinical outcomes.

Sign in to take quiz and track your certificates

Buy This Activity

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: March 7, 2022.

Published: April 22, 2022. doi:10.1001/jamanetworkopen.2022.8625

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Jacobs E et al. JAMA Network Open.

Corresponding Author: Emily Jacobs, MD, MS, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, 200 Hawkins Dr, Iowa City, IA 52242 (emily-jacobs@uiowa.edu).

Author Contributions: Drs Jacobs and Mejia had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Jacobs, Sparks, Mejia.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Jacobs.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Jacobs, Summers.

Administrative, technical, or material support: Jacobs, Sparks.

Supervision: Mejia.

Conflict of Interest Disclosures: None reported.

Meeting Presentation: This study was presented as an oral presentation at the annual meeting of the Pacific Coast Reproductive Society; March 25, 2022; Indian Wells, California.

References:
1.
Murewanhema  G .  Vaccination hesitancy among women of reproductive age in resource-challenged settings: a cause for public health concern.   Pan Afr Med J. 2021;38:336. doi:10.11604/pamj.2021.38.336.28953PubMedGoogle ScholarCrossref
2.
Centers for Disease Control and Prevention. COVID-19 vaccination among pregnant people aged 18-49 years overall, by race/ethnicity, and date reported to CDC- Vaccine Safety Datalink,*United States. Accessed February 18, 2022. https://covid.cdc.gov/covid-data-tracker/#vaccinations-pregnant-women
3.
Aharon  D , Lederman  M , Ghofranian  A ,  et al.  In vitro fertilization and early pregnancy outcomes after coronavirus disease 2019 (COVID-19) vaccination.   Obstet Gynecol. Published online January 25, 2022. doi:10.1097/AOG.0000000000004713PubMedGoogle ScholarCrossref
4.
Orvieto  R , Noach-Hirsh  M , Segev-Zahav  A , Haas  J , Nahum  R , Aizer  A .  Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle?   Reprod Biol Endocrinol. 2021;19(1):69. doi:10.1186/s12958-021-00757-6PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close