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Appendicitis has been reported as a potential adverse event after immunization with mRNA-based COVID-19 vaccines, based on trial data,1 adverse event report data,2 and observational data.3 We evaluated the risk of appendicitis after receiving an mRNA COVID-19 vaccination and after diagnosis of SARS-CoV-2 infection compared with the risk of appendicitis in unvaccinated individuals.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: March 6, 2022.
Published Online: April 25, 2022. doi:10.1001/jamainternmed.2022.1222
Corresponding Author: Helene Kildegaard, MD, Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 19/2, DK-5000 Odense C (firstname.lastname@example.org).
Author Contributions: Dr Kildegaard and Mr Pottegård had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Kildegaard, Rasmussen, Pottegård.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Kildegaard.
Critical revision of the manuscript for important intellectual content: Ladebo, Andersen, Jensen, Rasmussen, Damkier, Pottegård.
Statistical analysis: Kildegaard, Andersen, Jensen.
Obtained funding: Pottegård.
Administrative, technical, or material support: Ladebo.
Conflict of Interest Disclosures: Ms Rasmussen reported receiving support through the University of Southern Denmark from Novo Nordisk outside the submitted work. Mr Pottegård reported receiving grants from Alcon, Almirall, Astellas Pharma, AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Servier, and LEO Pharma outside the submitted work. No other disclosures were reported.
Additional Contributions: We thank Lars Christian Lund, MD, and Jesper Hallas, MD, from the University of Southern Denmark for valuable input into the methods used in this work. They were not compensated for their contributions.
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