[Skip to Content]
[Skip to Content Landing]

Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Appendicitis has been reported as a potential adverse event after immunization with mRNA-based COVID-19 vaccines, based on trial data,1 adverse event report data,2 and observational data.3 We evaluated the risk of appendicitis after receiving an mRNA COVID-19 vaccination and after diagnosis of SARS-CoV-2 infection compared with the risk of appendicitis in unvaccinated individuals.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: March 6, 2022.

Published Online: April 25, 2022. doi:10.1001/jamainternmed.2022.1222

Corresponding Author: Helene Kildegaard, MD, Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 19/2, DK-5000 Odense C (hckildegaard@health.sdu.dk).

Author Contributions: Dr Kildegaard and Mr Pottegård had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Kildegaard, Rasmussen, Pottegård.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Kildegaard.

Critical revision of the manuscript for important intellectual content: Ladebo, Andersen, Jensen, Rasmussen, Damkier, Pottegård.

Statistical analysis: Kildegaard, Andersen, Jensen.

Obtained funding: Pottegård.

Administrative, technical, or material support: Ladebo.

Supervision: Pottegård.

Conflict of Interest Disclosures: Ms Rasmussen reported receiving support through the University of Southern Denmark from Novo Nordisk outside the submitted work. Mr Pottegård reported receiving grants from Alcon, Almirall, Astellas Pharma, AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Servier, and LEO Pharma outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank Lars Christian Lund, MD, and Jesper Hallas, MD, from the University of Southern Denmark for valuable input into the methods used in this work. They were not compensated for their contributions.

References
1.
US Food and Drug Administration. Vaccines and related biological products advisory committee December 10, 2020 meeting announcement. December 10, 2020. Accessed December 14, 2021. https://www.fda.gov/advisory-committees/advisory-committee-calendar/vaccines-and-related-biological-products-advisory-committee-december-10-2020-meeting-announcement
2.
Mitchell  J , Yue  QY .  Appendicitis as a possible safety signal for the COVID-19 vaccines.   Vaccine X. 2021;9:100122. doi:10.1016/j.jvacx.2021.100122PubMedGoogle ScholarCrossref
3.
Barda  N , Dagan  N , Ben-Shlomo  Y ,  et al.  Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting.   N Engl J Med. 2021;385(12):1078-1090. doi:10.1056/NEJMoa2110475PubMedGoogle ScholarCrossref
4.
US Food and Drug Administration. COVID-19 vaccine safety surveillance. December 7, 2021, Accessed March 2, 2022. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/covid-19-vaccine-safety-surveillance
5.
Klein  NP , Lewis  N , Goddard  K ,  et al.  Surveillance for adverse events after COVID-19 mRNA vaccination.   JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072PubMedGoogle ScholarCrossref
6.
Kleif  J , Thygesen  LC , Gögenur  I .  Validity of the diagnosis of appendicitis in the Danish National Patient Register.   Scand J Public Health. 2020;48(1):38-42. doi:10.1177/1403494818761765PubMedGoogle ScholarCrossref
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close