A patient in their early 60s presented to the emergency department with 1 week of progressive weakness, myalgia, dyspnea, and ptosis. The patient’s medical history was significant for hepatocellular carcinoma, for which the patient had received radical surgery followed by an initial dose of camrelizumab 1 month before presentation. Vital signs on admission noted a blood pressure of 150/90 mm Hg, respiratory rate of 27 breaths per minute, heart rate of 108 beats per minute, and oxygen saturation of 92% on room air. Investigation revealed a creatinine phosphokinase level of 8156 U/L (reference range, <190 U/L), troponin I level of 1.47 ng/mL (reference range, <0.01 ng/mL; to convert to μg/L, multiply by 1), brain natriuretic peptide level of 267.3 pg/mL (reference range, <300 pg/mL), and a positive test result for acetylcholine receptor antibodies. Echocardiogram results showed a preserved left ventricular ejection fraction without wall-motion abnormalities. A routine electrocardiogram (ECG) performed 1 month earlier yielded normal results. The ECG obtained on this admission is shown in the Figure, A.
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Camrelizumab, a programmed cell death 1 (PD-1) inhibitor, represents a substantial advance for treating various cancers, including hepatocellular carcinoma.1 However, this comes at the cost of various immune-related adverse events (irAEs), among which ICI-related myocarditis remains a unique clinical challenge because of the heterogeneous presentations and potential life-threatening consequences. Many patients with ICI-related myocarditis might present with signs of heart failure, and up to 79% may develop left ventricular systolic dysfunction.2 However, the striking cardiac manifestation was conduction abnormality but not heart failure in this patient, suggesting a focal myocarditis that mainly involves the conduction system. It has been reported that 13% of patients with ICI-related cardiotoxic effects could manifest an isolated conduction disease with normal systolic function.2 Additionally, cardiac symptoms can often be masked by or coincident with other irAEs,3 such as myositis. Therefore, clinicians should be highly vigilant for the ICI-related myocarditis, particularly when noncardiac symptoms are present. As for the patient and family caregivers, they should receive up-to-date education about the clinical profile of myocarditis and other possible concurrent irAEs. Routine clinical follow-up and ECGs are necessary for the early detection of myocarditis, as ECGs appear to be one of the most sensitive tests of ICI-related myocarditis.3
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Authors: Lili Hong, MD, Department of Oncology, Tianjin Huanghe Hospital, Tianjin, People’s Republic of China (firstname.lastname@example.org); Tong Liu, MD, PhD, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China (email@example.com).
Published Online: April 25, 2022. doi:10.1001/jamainternmed.2022.1226
Conflict of Interest Disclosures: None were reported.
Additional Contributions: We thank Nan Zhang, MD, Second Hospital of Tianjin Medical University, and Gan-Xin Yan, PhD, Lankenau Medical Center, for their helpful comments. They were not compensated for their contributions.
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