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Congenital Defects

Unusual Basal Cell Carcinoma in an Adult Woman With Gorlin-Goltz Syndrome

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To identify the key insights or developments described in this article

1 Credit CME

JAMA Ophthalmology

Published Online: May 19, 2022

Ophthalmic Images

Article Information and Disclosures

Cam Loveridge-Easther, MBChB¹;

Robert Weatherhead, MBChB¹

Author Affiliations

¹Canterbury District Health Board, Christchurch, New Zealand

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A woman aged 66 years presented to the ophthalmology clinic for evaluation of an asymptomatic medial canthus mass of the left eye (Figure, A). Her medical history was significant for Gorlin-Goltz syndrome. Her best-corrected visual acuity was 6/9 OD and 6/7.5 OS. On examination, the medial canthus mass was noted to be noncontiguous with the periorbital skin. Biopsy of the lesion revealed conjunctival basal cell carcinoma (BCC) (Figure, B). The lesion was managed with 2 excisions and conjunctival patch grafting.

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Article Information

Corresponding Author: Cam Loveridge-Easther, MBChB, Unit 5, 11 Parlane St, Addington, Christchurch, New Zealand 8024 (cam.loveridge.easther@gmail.com).

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References

Cable MM , Lyon DB , Rupani M , Matta CS , Hidayat AA . Case reports and small case series: primary basal cell carcinoma of the conjunctiva with intraocular invasion. Arch Ophthalmol. 2000;118(9):1296-1298.doi:10.1001/archopht.118.9.1296 PubMed Google Scholar Crossref

Ash JE . Epibulbar tumors. Am J Ophthalmol. 1950;33(8):1203-1219. doi:10.1016/0002-9394(50)90990-1 PubMed Google Scholar Crossref

Moramarco A , Himmelblau E , Miraglia E , et al. Ocular manifestations in Gorlin-Goltz syndrome. Orphanet J Rare Dis. 2019;14(1):218. doi:10.1186/s13023-019-1190-6 PubMed Google Scholar Crossref

Shields CL , Alset AE , Boal NS , et al. Conjunctival tumors in 5002 cases: comparative analysis of benign vs malignant counterparts—the 2016 James D. Allen lecture. Am J Ophthalmol. 2017;173:106-133. doi:10.1016/j.ajo.2016.09.034 PubMed Google Scholar Crossref

Mudhar HS , Roy SR , Nuruddin M , Hoque F . Primary conjunctival pigmented basal cell carcinoma with increased numbers of intratumour melanocytes, mimicking melanoma: a case report and review of the literature. Ocul Oncol Pathol. 2020;6(3):168-173. doi:10.1159/000504413 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.