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Antithrombotic Therapy for Venous Thromboembolism

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1 Credit CME

Venous thromboembolism (VTE) includes superficial and deep vein thrombosis of the leg or pelvis and pulmonary embolism (PE).1 VTE affects an estimated 600 000 people in the US, with approximately 60 000 to 100 000 people dying from VTE and PE annually.2 Despite its prevalence, 25% to 40% of all VTE events are idiopathic, making diagnosis and prevention difficult.1

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Christopher D. Jackson, MD, Division of General Internal Medicine, Department of Medicine, University of Tennessee Health Science Center, 956 Court Ave, Memphis, TN 38163 (cjacks67@uthsc.edu).

Published Online: May 16, 2022. doi:10.1001/jama.2022.7325

Conflict of Interest Disclosures: None reported.

References
1.
Heit  JA , Spencer  FA , White  RH .  The epidemiology of venous thromboembolism.   J Thromb Thrombolysis. 2016;41(1):3-14. doi:10.1007/s11239-015-1311-6 PubMedGoogle ScholarCrossref
2.
Maughan  BC , Frueh  L , McDonagh  MS , Casciere  B , Kline  JA .  Outpatient treatment of low-risk pulmonary embolism in the era of direct oral anticoagulants: a systematic review.   Acad Emerg Med. 2021;28(2):226-239. doi:10.1111/acem.14108 PubMedGoogle ScholarCrossref
3.
Stevens  SM , Woller  SC , Kreuziger  LB ,  et al.  Antithrombotic therapy for VTE disease.   Chest. 2021;160(6):e545-e608. doi:10.1016/j.chest.2021.07.055 PubMedGoogle ScholarCrossref
4.
Aujesky  D , Obrosky  DS , Stone  RA ,  et al.  Derivation and validation of a prognostic model for pulmonary embolism.   Am J Respir Crit Care Med. 2005;172(8):1041-1046. doi:10.1164/rccm.200506-862OC PubMedGoogle ScholarCrossref
5.
Roy  PM , Penaloza  A , Hugli  O ,  et al; HOME-PE Study Group.  Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial.   Eur Heart J. 2021;42(33):3146-3157. doi:10.1093/eurheartj/ehab373 PubMedGoogle ScholarCrossref
6.
Kearon  C , Akl  EA , Ornelas  J ,  et al.  Antithrombotic therapy for VTE disease.   Chest. 2016;149(2):315-352. doi:10.1016/j.chest.2015.11.026 PubMedGoogle ScholarCrossref
7.
Kearon  C , Akl  EA , Comerota  AJ ,  et al.  Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines.   Chest. 2012;141(2)(suppl):e419S-e496S. doi:10.1378/chest.11-2301PubMedGoogle ScholarCrossref
8.
den Exter  PL , van Es  J , Klok  FA ,  et al.  Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism.   Blood. 2013;122(7):1144-1149. doi:10.1182/blood-2013-04-497545 PubMedGoogle ScholarCrossref
9.
Ikesaka  R , Carrier  M .  Clinical significance and management of subsegmental pulmonary embolism.   J Thromb Thrombolysis. 2015;39(3):311-314. doi:10.1007/s11239-015-1169-7 PubMedGoogle ScholarCrossref
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