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Chemotherapy-Induced Peripheral Neuropathy

To identify the key insights or developments described in this article
1 Credit CME

A man in his 70s with stage III colon cancer presented to a new primary care clinician to establish care. His only symptoms were numbness and occasional tingling in his fingers and toes. Eight months before, he had completed 3 months of adjuvant chemotherapy with capecitabine and oxaliplatin. His symptoms had started during the last month of chemotherapy, worsened for 2 months, and remained stable since. He had trouble tying his shoes and putting up delicate Christmas ornaments with his grandchildren. His only medication was losartan. He had no other neurological deficits.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Arjun Gupta, MD, Division of Hematology, Oncology & Transplantation, University of Minnesota, 516 Delaware St SE, MMC 480, PWB 14-100, Minneapolis, MN 55455 (arjgupta@umn.edu).

Published Online: May 31, 2022. doi:10.1001/jamainternmed.2022.1812

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for allowing us to share his story. We thank Anne Blaes, MD; Maryam Lustberg, MD; Charles Loprinzi, MD; Anil Makam, MD; and Ramy Sedhom, MD; for reviewing earlier versions of this article and providing critical input. They were not compensated for their work.

References
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2.
Jordan  B , Margulies  A , Cardoso  F ,  et al; ESMO Guidelines Committee.  Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up.   Ann Oncol. 2020;31(10):1306-1319. doi:10.1016/j.annonc.2020.07.003PubMedGoogle ScholarCrossref
3.
Winters-Stone  KM , Horak  F , Jacobs  PG ,  et al.  Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy.   J Clin Oncol. 2017;35(23):2604-2612. doi:10.1200/JCO.2016.71.3552PubMedGoogle ScholarCrossref
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Gupta  A , Nshuti  L , Grewal  US ,  et al.  Financial burden of drugs prescribed for cancer-associated symptoms.   JCO Oncol Pract. 2022;18(2):140-147.PubMedGoogle ScholarCrossref
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