Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 infection.1 A previous study that described MIS-C cases in the first 3 waves of the COVID-19 pandemic found that the proportion of individuals with severe illness declined after the first wave.2 In Israel, the Omicron (B.1.1.529) variant started to spread in November 2021.3 We describe outcomes of MIS-C in a multicenter cohort and assessed incidence nationally during the Alpha, Delta, and Omicron variant waves.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: April 27, 2022.
Published Online: May 19, 2022. doi:10.1001/jama.2022.8025
Corresponding Author: Itai Shavit, MD, PO Box 274, Kibbutz Maayan Tzvi 3080500, Israel (firstname.lastname@example.org).
Author Contributions: Drs Levy and Shavit had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Levy, Kaplan, Shavit.
Acquisition, analysis, or interpretation of data: Levy, Koppel, Yechiam, Shahar-Nissan, Kuchinski Cohen.
Drafting of the manuscript: Levy, Kaplan, Yechiam, Kuchinski Cohen, Shavit.
Critical revision of the manuscript for important intellectual content: Levy, Koppel, Kaplan, Shahar-Nissan, Kuchinski Cohen.
Statistical analysis: Shavit.
Administrative, technical, or material support: Koppel, Kaplan, Yechiam, Kuchinski Cohen.
Supervision: Levy, Shavit.
Conflict of Interest Disclosures: None reported.
Additional Contributions: In addition to the individuals recognized previously, we acknowledge the following individuals for their assistance with this study: Nachshon Buchshtav, MD (Pediatric Emergency Department, HaEmek Medical Center), for data collection; Giora Weiser, MD (Pediatric Emergency Department, Shaare Zedek Medical Center), for data collection and data assistance; Zeev Schnapp, MD (Pediatric Emergency Department, Carmel Medical Center), for data collection; and Irena Chistyakov, MD (Pediatric Emergency Department, Bnai Zion Medical Center), for data collection. None of these individuals received compensation for their roles in the study.
Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
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