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Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 infection.1 A previous study that described MIS-C cases in the first 3 waves of the COVID-19 pandemic found that the proportion of individuals with severe illness declined after the first wave.2 In Israel, the Omicron (B.1.1.529) variant started to spread in November 2021.3 We describe outcomes of MIS-C in a multicenter cohort and assessed incidence nationally during the Alpha, Delta, and Omicron variant waves.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: April 27, 2022.

Published Online: May 19, 2022. doi:10.1001/jama.2022.8025

Corresponding Author: Itai Shavit, MD, PO Box 274, Kibbutz Maayan Tzvi 3080500, Israel (itai@pem-database.org).

Author Contributions: Drs Levy and Shavit had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Levy, Kaplan, Shavit.

Acquisition, analysis, or interpretation of data: Levy, Koppel, Yechiam, Shahar-Nissan, Kuchinski Cohen.

Drafting of the manuscript: Levy, Kaplan, Yechiam, Kuchinski Cohen, Shavit.

Critical revision of the manuscript for important intellectual content: Levy, Koppel, Kaplan, Shahar-Nissan, Kuchinski Cohen.

Statistical analysis: Shavit.

Administrative, technical, or material support: Koppel, Kaplan, Yechiam, Kuchinski Cohen.

Supervision: Levy, Shavit.

Conflict of Interest Disclosures: None reported.

Additional Contributions: In addition to the individuals recognized previously, we acknowledge the following individuals for their assistance with this study: Nachshon Buchshtav, MD (Pediatric Emergency Department, HaEmek Medical Center), for data collection; Giora Weiser, MD (Pediatric Emergency Department, Shaare Zedek Medical Center), for data collection and data assistance; Zeev Schnapp, MD (Pediatric Emergency Department, Carmel Medical Center), for data collection; and Irena Chistyakov, MD (Pediatric Emergency Department, Bnai Zion Medical Center), for data collection. None of these individuals received compensation for their roles in the study.

References
1.
Information for health care providers about multisystem inflammatory syndrome in children. Centers for Disease Control and Prevention. Accessed April 12, 2022. https://www.cdc.gov/mis/hcp/index.html
2.
Miller  AD , Zambrano  LD , Yousaf  AR ,  et al; MIS-C Surveillance Authorship Group.  Multisystem inflammatory syndrome in children—United States, February 2020-July 2021.   Clin Infect Dis. Published online December 5, 2021. doi:10.1093/cid/ciab1007PubMedGoogle ScholarCrossref
3.
SARS-CoV-2 variants in analyzed sequences, Israel. Our World in Data. Accessed April 12, 2022. https://ourworldindata.org/grapher/covid-variants-area?country=~ISR
4.
COVID-19 reservoir. Data Gov. Accessed May 12, 2022. https://data.gov.il/dataset/covid-19
5.
Cloete  J , Kruger  A , Masha  M ,  et al.  Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 Omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study.   Lancet Child Adolesc Health. 2022;6(5):294-302. doi:10.1016/S2352-4642(22)00027-XPubMedGoogle ScholarCrossref
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