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Multisystem inflammatory syndrome in children (MIS-C) is a severe manifestation of SARS-CoV-2 in children and adolescents.1 We aimed to estimate the risk of MIS-C after SARS-CoV-2 infection in vaccinated and unvaccinated individuals during the Omicron wave. Further, we aimed to compare the risk and clinical characteristics of MIS-C with the pre-Omicron waves.
This population-based cohort study prospectively included patients aged 0 to 17 years with MIS-C from all 18 Danish pediatric departments. Patients were diagnosed from January 1, 2022, to March 15, 2022, after SARS-CoV-2 infection between January 1 and February 1, 2022, when Omicron constituted more than 95% of variants. We followed the STROBE reporting guidelines for cohort studies. We used previously reported data to compare MIS-C during Omicron with the pre-Omicron waves.1,2
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: May 4, 2022.
Published Online: June 8, 2022. doi:10.1001/jamapediatrics.2022.2206
Corresponding Author: Ulrikka Nygaard, MD, MPhil, PhD, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark (firstname.lastname@example.org).
Author Contributions: Dr Nygaard and Ms Espenhain had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Holm, Glenthoej, Schmidt, Brit Nordly, Hartling, Nygaard.
Acquisition, analysis, or interpretation of data: Holm, Espenhain, Glenthoej, Brit Nordly, Hartling, Nygaard.
Drafting of the manuscript: Holm, Espenhain, Glenthoej, Nygaard.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Holm, Espenhain, Nygaard.
Obtained funding: Nygaard.
Administrative, technical, or material support: Holm, Glenthoej, Schmidt, Nygaard.
Supervision: Brit Nordly, Hartling.
Conflict of Interest Disclosures: None reported.
Funding/Support: The study was supported by COVID-19 grant 0237-00004B from the National Ministry of Higher Education and Science and grant 0176-00020B from Innovation Fund Denmark.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
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